Evidence map›Paper›PMID 39012815›Full record

ArticleAmerican journal of respiratory cell and molecular biology2024

Investigation of CFTR Function in Human Nasal Epithelial Cells Informs Personalized Medicine.

Audrey Pion, Erin Kavanagh, Anya T Joynt, Karen S Raraigh, Lori Vanscoy, Elinor Langfelder-Schwind, John McNamara, Brooke Moore, Shivani Patel, Kate Merlo and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Audrey PionDepartment of Genetic Medicine.
Erin KavanaghDepartment of Genetic Medicine.
Anya T JoyntDepartment of Genetic Medicine.
Karen S RaraighDepartment of Genetic Medicine.
Lori VanscoyDepartment of Pediatrics, and.
Elinor Langfelder-SchwindLenox Hill Hospital, The Cystic Fibrosis Center, New York, New York; and.
John McNamaraChildren's Respiratory and Critical Care Specialists, Minneapolis, Minnesota.
Brooke MooreChildren's Respiratory and Critical Care Specialists, Minneapolis, Minnesota.
Shivani PatelDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Kate MerloDepartment of Genetic Medicine.
Renee TemmeGenetics Department, Children's Minnesota, Minneapolis, Minnesota.
Valeria CapurroUOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Emanuela PesceUOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Christian MerloDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Nicoletta PedemonteUOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Garry R CuttingDepartment of Genetic Medicine.
Neeraj SharmaDepartment of Genetic Medicine.

Funding

MOLECULAR GENETICS OF CYSTIC FIBROSISR01DK044003 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Garry R Cutting · 1991 to 2026
$6.7M
Molecular Genetics of Cystic FibrosisR37DK044003 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CUTTING, GARRY R · 2003 to 2012
$3.9M
Predoctoral Training Program in Human GeneticsT32GM148383 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Kimberly F Doheny, ANDREW S MCCALLION · 2023 to 2026
$2.4M
Cystic Fibrosis Foundation PEDEMO20G0NIDDK NIH HHS R01 DK044003NIDDK NIH HHS R37 DK044003NIGMS NIH HHS T32 GM148383NIGMS NIH HHS T32GM148383NIH HHS DK044003Spruance FoundationVertex Pharmaceuticals Research Innovation Award
6 · The paper itself

Abstract

We broaden the clinical versatility of human nasal epithelial (HNE) cells. HNEs were isolated from 10 participants harboring

Indexed as

AminophenolsCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsNasal MucosaPrecision MedicineQuinolonesAdultBenzodioxolesCells, CulturedChloride Channel AgonistsDrug CombinationsFemaleHumansIndolesMaleAminophenolsBenzodioxolesCFTR protein, humanChloride Channel AgonistsCystic Fibrosis Transmembrane Conductance RegulatorDrug CombinationsIndolesivacaftorPyrazolesPyridinesPyrrolesQuinolonestezacaftor5Tair–liquid interfacecystic fibrosismodulatorsnasal epithelial

Identifiers

PMID39012815
PMCPMC11568479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.