ReviewAging and disease2024
Exercise-Induced Central Fatigue: Biomarkers and Non-Medicinal Interventions.
Review in Aging and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Natural products alleviate exercise-induced fatigue by modulating gut microbiota: a systematic review.Journal of the International Society of Sports Nutrition · 2026Pooled it
- A Dual-Modal Biosensing Approach to Evaluate Cortico-Muscular Coupling in Adolescent Idiopathic Scoliosis.Biosensors · 2026Article
- Hitting the Wall in Marathon Running: An Integrative Psychophysiological and Durability-Based Review.Journal of functional morphology and kinesiology · 2026Review
- Article
- Research Progress on the Prevention and Treatment of Exercise-Induced Fatigue by Acupuncture.Healthcare (Basel, Switzerland) · 2026Review
- The Role of Nootropic Supplements in Sports: Enhancing Cognitive and Physical Performance Simultaneously.Food science & nutrition · 2026Review
- Finishing Barrow Skeletal Muscle Performance and Fatigue Response to Large-Dose Nicotinamide Riboside Supplementation.Metabolites · 2026Article
- Article
- Pre-exercise mood, sex-specific hormonal and neuromodulatory responses to maximal exertion in elite rowers.Frontiers in physiology · 2026Article
- Research on changes in psychological, physical fatigue and emotional states in the National Youth Orienteering Preparation Camp.Scientific reports · 2025Article
- Supplementation with Live and Heat-TreatedNutrients · 2025Article
- Establishing the minimal important difference of the visual analog scale for assessing exercise-induced fatigue.BMC sports science, medicine & rehabilitation · 2025Article
- Diurnal variation in skeletal muscle mitochondrial function dictates time-of-day-dependent exercise capacity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatigue, commonly experienced in daily life, is a feeling of extreme tiredness, shortage or lack of energy, exhaustion, and difficulty in performing voluntary tasks. Central fatigue, defined as a progressive failure to voluntarily activate the muscle, is typically linked to moderate- or light-intensity exercise. However, in some instances, high-intensity exercise can also trigger the onset of central fatigue. Exercise-induced central fatigue often precedes the decline in physical performance in well-trained athletes. This leads to a reduction in nerve impulses, decreased neuronal excitability, and an imbalance in brain homeostasis, all of which can adversely impact an athlete's performance and the longevity of their sports career. Therefore, implementing strategies to delay the onset of exercise-induced central fatigue is vital for enhancing athletic performance and safeguarding athletes from the debilitating effects of fatigue. In this review, we discuss the structural basis, measurement methods, and biomarkers of exercise-induced central fatigue. Furthermore, we propose non-pharmacological interventions to mitigate its effects, which can potentially foster improvements in athletes' performances in a healthful and sustainable manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.