Evidence map›Paper›PMID 39012566›Full record

ArticleMolecular diversity2025

Efficient synthesis and evaluation of therapeutic potential of fluorine containing 2-arylchromen-4-ones.

Nadezhda Troshkova, Larisa Politanskaya, Jiaying Wang, Maria Niukalova, Shokhrukh Khasanov, Iana Esaulkova, Vladimir Zarubaev, Natalia Boltneva, Elena Rudakova, Nadezhda Kovaleva and 11 more

Abstract read
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In one paragraph

Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Nadezhda TroshkovaVorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Ac. Lavrentiev Avenue, 9, Novosibirsk, 630090, Russian Federation.
Larisa PolitanskayaVorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Ac. Lavrentiev Avenue, 9, Novosibirsk, 630090, Russian Federation. plv@nioch.nsc.ru.ORCID https://orcid.org/0000-0003-1374-8213
Jiaying WangVorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Ac. Lavrentiev Avenue, 9, Novosibirsk, 630090, Russian Federation.
Maria NiukalovaSaint-Petersburg Pasteur Institute, Mira Street, 14, Saint-Petersburg, 197101, Russian Federation.
Shokhrukh KhasanovSaint-Petersburg Pasteur Institute, Mira Street, 14, Saint-Petersburg, 197101, Russian Federation.
Iana EsaulkovaSaint-Petersburg Pasteur Institute, Mira Street, 14, Saint-Petersburg, 197101, Russian Federation.ORCID https://orcid.org/0000-0002-3645-8342
Vladimir ZarubaevSaint-Petersburg Pasteur Institute, Mira Street, 14, Saint-Petersburg, 197101, Russian Federation.ORCID https://orcid.org/0000-0002-5224-3771
Natalia BoltnevaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, 142432, Russian Federation.ORCID https://orcid.org/0000-0002-7171-8832
Elena RudakovaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, 142432, Russian Federation.ORCID https://orcid.org/0000-0002-4600-7799
Nadezhda KovalevaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, 142432, Russian Federation.ORCID https://orcid.org/0000-0002-4990-5068
Olga SerebryakovaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, 142432, Russian Federation.ORCID https://orcid.org/0000-0002-0313-1423
Galina MakhaevaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, 142432, Russian Federation.ORCID https://orcid.org/0000-0002-8136-6906
Nikita ValuiskyVolgograd State Medical University, Pavshikh Bortsov Sq. 1, Volgograd, 400131, Russian Federation.ORCID https://orcid.org/0009-0000-8539-6590
Umida IbragimovaVolgograd State Medical University, Pavshikh Bortsov Sq. 1, Volgograd, 400131, Russian Federation.ORCID https://orcid.org/0000-0001-9141-4417
Roman LitvinovVolgograd State Medical University, Pavshikh Bortsov Sq. 1, Volgograd, 400131, Russian Federation.ORCID https://orcid.org/0000-0002-0162-0653
Denis BabkovVolgograd State Medical University, Pavshikh Bortsov Sq. 1, Volgograd, 400131, Russian Federation.ORCID https://orcid.org/0000-0002-9645-3324
Kubanych UsenovZelman Institute of Medicine and Psychology, Novosibirsk State University, Pirogova Street, 1, Novosibirsk, 630090, Russian Federation.ORCID https://orcid.org/0009-0004-4062-5483
Matvey ChertenkovZelman Institute of Medicine and Psychology, Novosibirsk State University, Pirogova Street, 1, Novosibirsk, 630090, Russian Federation.ORCID https://orcid.org/0009-0008-2589-2902
Mikhail PokrovskyZelman Institute of Medicine and Psychology, Novosibirsk State University, Pirogova Street, 1, Novosibirsk, 630090, Russian Federation.
Sergey CheresizZelman Institute of Medicine and Psychology, Novosibirsk State University, Pirogova Street, 1, Novosibirsk, 630090, Russian Federation.ORCID https://orcid.org/0000-0001-8852-2265
Andrey PokrovskyZelman Institute of Medicine and Psychology, Novosibirsk State University, Pirogova Street, 1, Novosibirsk, 630090, Russian Federation.ORCID https://orcid.org/0000-0001-5982-8580

Funding

Russian Science Support Foundation 23-23-00008
6 · The paper itself

Abstract

A large series of 2-arylchromen-4-ones containing from 1 to 3 fluorine atoms or a trifluoromethyl group in the structure was synthesized by condensation of fluorinated 2-hydroxyacetophenones with benzaldehydes in an alkaline medium and subsequent oxidative cyclization of the resulting 2'-hydroxychalcones by action of I

Indexed as

Antiviral AgentsBenzopyransFluorineAnimalsAntioxidantsButyrylcholinesteraseCell Line, TumorChlorocebus aethiopsDogsHalogenationHumansInfluenza A Virus, H1N1 SubtypeMadin Darby Canine Kidney CellsStructure-Activity RelationshipVero CellsAntioxidantsAntiviral AgentsBenzopyransButyrylcholinesteraseFluorineAnti-glycation activityAnti-influenza virus activityCytotoxicityEsterase profileFluorinated flavones

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.