ArticleApplied microbiology and biotechnology2024
Effect of L-HSL on biofilm and motility of Pseudomonas aeruginosa and its mechanism.
Article in Applied microbiology and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Piperonylpiperazine Targets RhlI to Reduce Virulence and Potentiate EDTA Sensitivity inFoods (Basel, Switzerland) · 2026Article
- Inhibitory effects of esculetin as a quorum sensing inhibitor on biofilm formation and virulence factors in Vibrio anguillarum.World journal of microbiology & biotechnology · 2026Article
- Regulation of drug resistance and virulence ofFrontiers in microbiology · 2026Article
- Review
- Synthesis of N-acyl-homoserine lactones analogs for improving the potential application of Acidithiobacillus thiooxidans in bioleaching.Archives of microbiology · 2025Article
- Anti-QS Strategies AgainstMicroorganisms · 2025Review
- Anti-Virulence Efficacy of Chinese Dragon's Blood AgainstInfection and drug resistance · 2025Article
- Transcriptome Analysis Reveals the Mechanism of Y0-C10-HSL on Biofilm Formation and Motility ofPharmaceuticals (Basel, Switzerland) · 2024Article
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Authors and funding
7 authors.
Funding
Abstract
Pseudomonas aeruginosa (P. aeruginosa) biofilm formation is a crucial cause of enhanced antibiotic resistance. Quorum sensing (QS) is involved in regulating biofilm formation; QS inhibitors block the QS signaling pathway as a new strategy to address bacterial resistance. This study investigated the potential and mechanism of L-HSL (N-(3-cyclic butyrolactone)-4-trifluorophenylacetamide) as a QS inhibitor for P. aeruginosa. The results showed that L-HSL effectively inhibited the biofilm formation and dispersed the pre-formed biofilm of P. aeruginosa. The production of extracellular polysaccharides and the motility ability of P. aeruginosa were suppressed by L-HSL. C. elegans infection experiment showed that L-HSL was non-toxic and provided protection to C. elegans against P. aeruginosa infection. Transcriptomic analysis revealed that L-HSL downregulated genes related to QS pathways and biofilm formation. L-HSL exhibits a promising potential as a therapeutic drug for P. aeruginosa infection. KEY POINTS: • Chemical synthesis of N-(3-cyclic butyrolactone)-4-trifluorophenylacetamide, named L-HSL. • L-HSL does not generate survival pressure on the growth of P. aeruginosa and can inhibit the QS system. • KEGG enrichment analysis found that after L-HSL treatment, QS-related genes were downregulated.
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Registered trials
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