Evidence map›Paper›PMID 39012500›Full record

Trial reportJNCI cancer spectrum2024

Effect of resistance training on physical function during chemotherapy in colon cancer.

Justin C Brown, Shengping Yang, Stephanie L E Compton, Kristin L Campbell, Elizabeth M Cespedes Feliciano, Sara Quinney, Barbara Sternfeld, Bette J Caan, Jeffrey A Meyerhardt, Kathryn H Schmitz

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JNCI cancer spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03291951 (FOcus on Reducing Dose-limiting Toxicities in Colon Cancer With Resistance Exercise Study), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03291951 nacompletednot on this map

FOcus on Reducing Dose-limiting Toxicities in Colon Cancer With Resistance Exercise Study

TypeinterventionalSponsorKaiser PermanenteRan2018 to 2022Enrolled183ConditionsResistance Training, Colon Cancer, Chemotherapy EffectArmsResistance training
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Justin C BrownPennington Biomedical Research Center, Baton Rouge, LA, USA.ORCID 0000-0001-7540-4913
Shengping YangPennington Biomedical Research Center, Baton Rouge, LA, USA.
Stephanie L E ComptonPennington Biomedical Research Center, Baton Rouge, LA, USA.
Kristin L CampbellUniversity of British Columbia, Vancouver, BC, Canada.
Elizabeth M Cespedes FelicianoKaiser Permanente Northern California, Oakland, CA, USA.ORCID 0000-0003-1192-4017
Sara QuinneyIndiana University School of Medicine, Indianapolis, IN, USA.
Barbara SternfeldKaiser Permanente Northern California, Oakland, CA, USA.
Bette J CaanIndiana University School of Medicine, Indianapolis, IN, USA.
Jeffrey A MeyerhardtDana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-1120-0898
Kathryn H SchmitzUniversity of Pittsburgh, Pittsburgh, PA, USA.

Funding

Resistance Training to Reduce Chemotoxicity in Colon CancerR01CA206196 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI CAAN, BETTE J, MEYERHARDT, JEFFREY A · 2017 to 2021
$4.1M
National Cancer Institute of the National Institutes of HealthNCI NIH HHS R01 CA206196
6 · The paper itself

Abstract

backgroundThe decline of physical function during chemotherapy predicts poor quality of life and premature death. It is unknown if resistance training prevents physical function decline during chemotherapy in colon cancer survivors.

methodsThis multicenter trial randomly assigned 181 colon cancer survivors receiving postoperative chemotherapy to home-based resistance training or usual care control. Physical function outcomes included the short physical performance battery, isometric handgrip strength, and the physical function subscale of the Medical Outcomes Short-Form 36-item questionnaire. Mixed models for repeated measures quantified estimated treatment differences.

resultsAt baseline, participants had a mean (SD) age of 55.2 (12.8) years; 67 (37%) were 60 years or older, and 29 (16%) had a composite short physical performance battery score of no more than 9. Compared with usual care control, resistance training did not improve the composite short physical performance battery score (estimated treatment difference = -0.01, 95% confidence interval [CI] = -0.32 to 0.31; P = .98) or the short physical performance battery scores for balance (estimated treatment difference = 0.01, 95% CI = -0.10 to 0.11; P = .93), gait speed (estimated treatment difference = 0.08, 95% CI = -0.06 to 0.22; P = .28), and sit-to-stand (estimated treatment difference = -0.08, 95% CI = -0.29 to 0.13; P = .46). Compared with usual care control, resistance training did not improve isometric handgrip strength (estimated treatment difference = 1.50 kg, 95% CI = -1.06 to 4.05; P = .25) or self-reported physical function (estimated treatment difference = -3.55, 95% CI = -10.03 to 2.94); P = .28). The baseline short physical performance battery balance score (r = 0.21, 95% CI = 0.07 to 0.35) and handgrip strength (r = 0.23, 95% CI = 0.09 to 0.36) correlated with chemotherapy relative dose intensity.

conclusionAmong colon cancer survivors with relatively high physical functioning, random assignment to home-based resistance training did not prevent physical function decline during chemotherapy. CLINICAL

trial registrationNCT03291951.

Indexed as

Colonic NeoplasmsHand StrengthPhysical Functional PerformanceQuality of LifeResistance TrainingAdultAgedCancer SurvivorsFemaleHumansMaleMiddle AgedPostural BalanceWalking Speed

Identifiers

PMID39012500
PMCPMC11285783

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.