Evidence map›Paper›PMID 39012486›Full record

ArticleJournal of the American Chemical Society2024

Spatially Localized Entropy-Driven Evolution of Nucleic Acid-Based Constitutional Dynamic Networks for Intracellular Imaging and Spatiotemporal Programmable Gene Therapy.

Nina Lin, Yu Ouyang, Yunlong Qin, Ola Karmi, Yang Sung Sohn, Songqin Liu, Rachel Nechushtai, Yuanjian Zhang, Itamar Willner, Zhixin Zhou

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Nucleic Acid-Modified Nanoparticles for Cancer Therapeutic Applications.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nina LinSchool of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
Yu OuyangInstitute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.ORCID 0000-0002-2418-281X
Yunlong QinInstitute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Ola KarmiInstitute of Life Science, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Yang Sung SohnInstitute of Life Science, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Songqin LiuSchool of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.ORCID 0000-0002-4686-5291
Rachel NechushtaiInstitute of Life Science, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.ORCID 0000-0002-3219-954X
Yuanjian ZhangSchool of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.ORCID 0000-0003-2932-4159
Itamar WillnerInstitute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.ORCID 0000-0001-9710-9077
Zhixin ZhouSchool of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.ORCID 0000-0003-0450-1921

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The primer-guided entropy-driven high-throughput evolution of the DNA-based constitutional dynamic network, CDN, is introduced. The entropy gain associated with the process provides a catalytic principle for the amplified emergence of the CDN. The concept is applied to develop a programmable, spatially localized DNA circuit for effective

Indexed as

DNAEntropyGenetic TherapyMicroRNAsAnimalsBreast NeoplasmsCell Line, TumorDNA, CatalyticEarly Growth Response Protein 1FemaleHumansHypoxia-Inducible Factor 1, alpha SubunitMiceRNA, Small InterferingDNADNA, CatalyticEarly Growth Response Protein 1Hypoxia-Inducible Factor 1, alpha SubunitMicroRNAsMIRN21 microRNA, humanRNA, Small Interfering

Identifiers

PMID39012486
PMCPMC11295181

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.