Evidence map›Paper›PMID 39012471›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2024

Outcomes in solid organ transplant recipients receiving organs from a donor with Fusarium solani species complex meningitis.

Isabel S Griffin, Dallas J Smith, Pallavi Annambhotla, Jeremy A W Gold, Luis Ostrosky-Zeichner, Carol A Kauffman, Lalitha Gade, Anastasia Litvintseva, Daniel Zp Friedman, Angie G Nishio Lucar and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Isabel S GriffinDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-4113-8412
Dallas J SmithMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-5707-528X
Pallavi AnnambhotlaDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-5564-8785
Jeremy A W GoldMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-5054-7616
Luis Ostrosky-ZeichnerDivision of Infectious Diseases, McGovern Medical School, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-4784-7589
Carol A KauffmanDivision of Infectious Diseases, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Lalitha GadeMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-9264-9952
Anastasia LitvintsevaMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-1086-8041
Daniel Zp FriedmanSection of Infectious Diseases and Global Health, University of Chicago Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-3442-7454
Angie G Nishio LucarDepartment of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0003-1326-3013
Tarina C ParpiaDepartment of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0001-9808-9928
Joshua LiebermanUniversity of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-0376-1337
Janet BujanHouston Methodist Hospital, Houston, Texas, USA.
Julie CorkreanHouston Methodist Hospital, Houston, Texas, USA.
Mukul K DivatiaDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-4058-2335
Kevin GrimesHouston Methodist Hospital, Houston, Texas, USA.
Jiejian LinHouston Methodist Hospital, Houston, Texas, USA.
Constance MobleyHouston Methodist Hospital, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-3925-4975
Mary R SchwartzDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Bashar HannawiTransplant Institute, Henry Ford Hospital, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0001-5764-549X
Anne MalilayTransplant Institute, Henry Ford Hospital, Detroit, Michigan, USA.
Anne O'BoyeCanning Thoracic Institute, Northwestern Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0009-0008-5711-2122
Jeffrey LysneCanning Thoracic Institute, Northwestern Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0009-0009-9588-7858
Mrinalini Venkata SubramaniCanning Thoracic Institute, Northwestern Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-3545-2747
Hayley HeckmannTexas Organ Sharing Alliance, Austin, Texas, USA.
Venice ServellitaDepartment of Laboratory Medicine and Medicine, Division of Infectious Diseases and UCSF Clinical Microbiology Laboratory, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-1745-4012
Charles ChiuDepartment of Laboratory Medicine and Medicine, Division of Infectious Diseases and UCSF Clinical Microbiology Laboratory, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0003-2915-2094
Sridhar V BasavarajuDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-8376-0499

Funding

Biomedical Advanced Research and Development Authority 75A50122C00022Chan-Zuckerberg BiohubIntramural CDC HHS CC999999US Centers for Disease Control and Prevention 75D30121C12641
6 · The paper itself

Abstract

backgroundFive organs (heart, right lung, liver, right, and left kidneys) from a deceased patient were transplanted into five recipients in four US states; the deceased patient was identified as part of a healthcare-associated fungal meningitis outbreak among patients who underwent epidural anesthesia in Matamoros, Mexico.

methodsAfter transplant surgeries occurred, Fusarium solani species complex, a fungal pathogen with a high case-mortality rate, was identified in cerebrospinal fluid from the organ donor by metagenomic next-generation sequencing (mNGS) and fungal-specific polymerase chain reaction and in plasma by mNGS.

resultsFour of five transplant recipients received recommended voriconazole prophylaxis; four were monitored weekly by serum (1-3)-β-d-glucan testing. All five were monitored for signs of infection for at least 3 months following transplantation. The liver recipient had graft failure, which was attributed to an etiology unrelated to fungal infection. No fungal DNA was identified in sections of the explanted liver, suggesting that F. solani species complex did not contribute to graft failure. The remaining recipients experienced no signs or symptoms suggestive of fusariosis.

conclusionAntifungal prophylaxis may be useful in preventing donor-derived infections in recipients of organs from donors that are found to have Fusarium meningitis.

Indexed as

Antifungal AgentsFusariosisFusariumMeningitis, FungalTissue DonorsTransplant RecipientsVoriconazoleAdultAgedFemaleHigh-Throughput Nucleotide SequencingHumansKidney TransplantationLiver TransplantationMaleMiddle AgedAntifungal AgentsVoriconazolefungal meningitisfusarium

Identifiers

PMID39012471
PMCPMC11915123

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.