Evidence map›Paper›PMID 39012429›Full record

ArticleJournal of periodontology2025

Disparate effects of sclerostin deletion on alveolar bone and cellular cementum in mice.

Aonjittra Phanrungsuwan, Michael B Chavez, Leena A Eltilib, Tamara N Kolli, Fatma F Mohamed, Michelle H Tan, Cristiane R Salmon, Francisco H Nociti, Brian L Foster

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In one paragraph

Article in Journal of periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aonjittra PhanrungsuwanDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-1848-0335
Michael B ChavezDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-0893-2139
Leena A EltilibDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.
Tamara N KolliDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.
Fatma F MohamedDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.
Michelle H TanDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.
Cristiane R SalmonDepartment of Prosthodontics and Periodontics, Division of Periodontics, Piracicaba Dental School, State University of Campinas, São Paulo, Brazil.
Francisco H NocitiDepartment of Prosthodontics and Periodontics, Division of Periodontics, Piracicaba Dental School, State University of Campinas, São Paulo, Brazil.
Brian L FosterDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-3444-0576

Funding

Identifying Novel Mechanisms for Dentoalveolar Mineralization Defects in X-linked HypophosphatemiaR01DE032334 · NIDCR · OHIO STATE UNIVERSITY · PI Brian Lee Foster · 2022 to 2026
$2.5M
Function of cementocytes in cellular cementum formation and resorptionR03DE028632 · NIDCR · OHIO STATE UNIVERSITY · PI FOSTER, BRIAN LEE · 2019 to 2020
$307k
NIDCR NIH HHS R01 DE032334NIDCR NIH HHS R01DE032334NIDCR NIH HHS R03 DE028632NIDCR NIH HHS R03DE028632
6 · The paper itself

Abstract

backgroundCellular cementum (CC) includes cementocytes, cells suspected to regulate CC formation or resorption as osteocytes do in bone. Sclerostin (SOST) is a secreted negative regulator of Wnt/β-catenin signaling expressed by osteocytes and cementocytes. Osteocyte SOST expression reduces bone formation. We investigated the functional importance of SOST in CC compared with alveolar bone (AB) using a Sost knockout (Sost

methodsMandibles and femurs of Sost

resultsFemur cortical and trabecular bone and mandibular bone volumes were similarly increased in Sost

conclusionsThese data indicate CC is less responsive than AB to SOST deletion. Within the study limitations, these results do not support cementocytes as critical for directing increased CC formation. PLAIN LANGUAGE SUMMARY: Sclerostin is a protein known to inhibit bone formation, and removing sclerostin leads to more bone formation. Cementum is the thin layer that covers the surface of the tooth's root. Previous studies suggest that inhibiting sclerostin can similarly increase the amount of cementum. We wanted to compare the response of cementum and bone when sclerostin is absent to understand similarities and differences between these two tissues. In this study, we removed the Sost gene (the gene which produces sclerostin) in mice. We found that mice without sclerostin have more bone in their legs and jaws. Moreover, mice without sclerostin also healed better after tooth removal compared with normal mice. Surprisingly, unlike previous studies, we found that the amount of cementum was not different in mice without sclerostin compared with normal mice. Additionally, we challenged the cementum by taking out the opposing tooth to cause the first mandibular molar to move up by building more cementum. Even with this challenge, we found no difference in the amount of cementum in mice lacking sclerostin compared with normal mice. Therefore, we conclude here that cementum is less sensitive to the absence of sclerostin compared with bone.

Indexed as

Alveolar ProcessDental CementumGlycoproteinsAdaptor Proteins, Signal TransducingAnimalsCell Adhesion MoleculesFemurIntercellular Signaling Peptides and ProteinsMandibleMiceMice, Inbred C57BLMice, KnockoutMolarOsteocytesWnt Signaling PathwayX-Ray MicrotomographyAdaptor Proteins, Signal TransducingCell Adhesion MoleculesGlycoproteinsIntercellular Signaling Peptides and ProteinsPostn protein, mouseSost protein, mouseboneextracellular matrixmineralizationperiodontiumtooth development

Identifiers

PMID39012429
PMCPMC11735692

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.