Evidence map›Paper›PMID 39012393›Full record

ArticleFunctional & integrative genomics2024

A novel antitumor mechanism of triptonide in colorectal cancer: inducing ferroptosis via the SLC7A11/GPX4 axis.

Weijie Wang, Xiaofen Zhao, Jie Zhou, Hai Li

Abstract read
PubMed Publisher
In one paragraph

Article in Functional & integrative genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Weijie Wang *Department of Colorectal Surgery, General Hospital of Ningxia Medical University, Ningxia Hui Autonomous Region, No. 804 Shengli South Street, Xingqing District, Yinchuan City, 750004, China.
Xiaofen Zhao *Department of Colorectal Surgery, General Hospital of Ningxia Medical University, Ningxia Hui Autonomous Region, No. 804 Shengli South Street, Xingqing District, Yinchuan City, 750004, China.
Jie ZhouDepartment of Colorectal Surgery, General Hospital of Ningxia Medical University, Ningxia Hui Autonomous Region, No. 804 Shengli South Street, Xingqing District, Yinchuan City, 750004, China.
Hai LiDepartment of Colorectal Surgery, General Hospital of Ningxia Medical University, Ningxia Hui Autonomous Region, No. 804 Shengli South Street, Xingqing District, Yinchuan City, 750004, China. ctbaby2021@163.com.

Funding

Natural Science Foundation of Ningxia Province 2022AAC03571
6 · The paper itself

Abstract

Colorectal cancer (CRC) is a prevalent malignancy affecting the human digestive tract. Triptonide has been shown to have some anticancer activity, but its effect in CRC is vague. Herein, we examined the effect of triptonide on CRC. In this study, the results of bioinformatics analysis displayed that triptonide may regulate ferroptosis in CRC by modulating GPX4 and SLC7A11. In HCT116 and LoVo cells, the expression levels of GPX4 and SLC7A11 were significantly reduced after triptonide management versus the control group. Triptonide inhibited proliferation, but promoted ferroptosis in CRC cells. SLC7A11 upregulation overturned the effects of triptonide on proliferation and ferroptosis in CRC cells. Triptonide inhibited activation of the PI3K/AKT/Nrf2 signaling in CRC cells. Activation of the PI3K/AKT signaling or Nrf2 upregulation overturned the effects of triptonide on proliferation and ferroptosis in CRC cells. Triptonide suppressed CRC cell growth in vivo by modulating SLC7A11 and GPX4. In conclusion, Triptonide repressed proliferation and facilitated ferroptosis of CRC cells by repressing the SLC7A11/GPX4 axis through inactivation of the PI3K/AKT/Nrf2 signaling.

Indexed as

Amino Acid Transport System y+Cell ProliferationColorectal NeoplasmsFerroptosisPhospholipid Hydroperoxide Glutathione PeroxidaseSignal TransductionAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHCT116 CellsHumansMiceMice, NudeNF-E2-Related Factor 2Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAmino Acid Transport System y+NFE2L2 protein, humanNF-E2-Related Factor 2Phosphatidylinositol 3-KinasesPhospholipid Hydroperoxide Glutathione PeroxidaseProto-Oncogene Proteins c-aktSLC7A11 protein, humantriptonideTriterpenesColorectal cancerFerroptosisPI3K/AKT/Nrf2 signalingProliferationTriptonide

Identifiers

PMID39012393

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.