Evidence map›Paper›PMID 39012226›Full record

Trial reportAmerican journal of respiratory and critical care medicine2024

Pyrazinamide Safety, Efficacy, and Dosing for Treating Drug-Susceptible Pulmonary Tuberculosis: A Phase 3, Randomized Controlled Clinical Trial.

Ava Y Xu, Gustavo E Velásquez, Nan Zhang, Vincent K Chang, Patrick P J Phillips, Payam Nahid, Susan E Dorman, Ekaterina V Kurbatova, William C Whitworth, Erin Sizemore and 11 more

Abstract readRandomized Controlled TrialClinical Trial, Phase III
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Pharmacokinetic and pharmacogenomic predictors of hepatotoxicity in the HIRIF trial for drug-susceptible tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  3. Article
  4. The journal of physical chemistry. B · 2025
    Article
  5. Anti-TB Drugs for Drug-Sensitive and Drug-ResistantCurrent issues in molecular biology · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. A Balancing Act: Finding the Right Dose of Pyrazinamide to Treat Tuberculosis.American journal of respiratory and critical care medicine · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Ava Y XuDepartment of Bioengineering and Therapeutic Sciences.ORCID 0000-0002-9222-1227
Gustavo E VelásquezUCSF Center for Tuberculosis.ORCID 0000-0003-1438-0692
Nan ZhangDepartment of Bioengineering and Therapeutic Sciences.
Vincent K ChangDepartment of Bioengineering and Therapeutic Sciences.
Patrick P J PhillipsUCSF Center for Tuberculosis.ORCID 0000-0002-6336-7024
Payam NahidUCSF Center for Tuberculosis.ORCID 0000-0003-2811-1311
Susan E DormanMedical University of South Carolina, Charleston, South Carolina.ORCID 0000-0001-6882-9470
Ekaterina V KurbatovaCDC, Atlanta, Georgia.
William C WhitworthCDC, Atlanta, Georgia.ORCID 0000-0001-5306-548X
Erin SizemoreCDC, Atlanta, Georgia.ORCID 0000-0003-3232-0546
Kia BryantCDC, Atlanta, Georgia.
Wendy CarrCDC, Atlanta, Georgia.
Nicole E BrownCDC, Atlanta, Georgia.ORCID 0000-0002-3184-0550
Melissa L EngleUniversity of Texas Health Science Center at San Antonio and the South Texas Veterans Health Care System, San Antonio, Texas.
Nguyen Viet NhungVietnam National Tuberculosis Program-University of California, San Francisco Research Collaboration Unit, Hanoi, Vietnam.
Pheona NsubugaUganda-Case Western Reserve University Research Collaboration, Kampala, Uganda.
Andreas DiaconTASK, Cape Town, South Africa.
Kelly E DooleyDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0001-9013-5256
Richard E ChaissonSchool of Medicine, John Hopkins University, Baltimore, Maryland; and.
Susan SwindellsUniversity of Nebraska Medical Center, Omaha, Nebraska.
Radojka M SavicDepartment of Bioengineering and Therapeutic Sciences.

Funding

Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6M
Validation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8M
Identifying Optimal Treatment Strategies for Tuberculosis TreatmentR01AI135124 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALLAND, DAVID, SAVIC, RADOJKA · 2019 to 2023
$3.8M
Novel Biomarkers to Shorten TB TreatmentR01AI126788 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI ALLAND, DAVID, DORMAN, SUSAN E · 2016 to 2020
$3.5M
Safety and tolerability of new and repurposed drugs for MDR-TB treatmentK08AI141740 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VELASQUEZ, GUSTAVO EDUARDO · 2019 to 2023
$985k
Mentoring Investigators in HIV and Tuberculosis Therapeutics ResearchK24AI150349 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DOOLEY, KELLY E. · 2020 to 2025
$789k
NIAID NIH HHS K08 AI141740NIAID NIH HHS K24 AI150349NIAID NIH HHS R01 AI126788NIAID NIH HHS R01 AI135124NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI106701
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antitubercular AgentsPyrazinamideTuberculosis, PulmonaryAdultDose-Response Relationship, DrugFemaleHumansMaleMiddle AgedTreatment OutcomeYoung AdultAntitubercular AgentsPyrazinamidedose–responseexposure–responsepopulation pharmacokineticspyrazinamidetuberculosis

Identifiers

PMID39012226
PMCPMC11622436

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.