Evidence map›Paper›PMID 39011957›Full record

ArticleThe Journal of infectious diseases2024

Prepandemic Metabolic Correlates of Coronavirus Disease 2019 (COVID-19) Severity and Long COVID Incidence in People Living With HIV.

Priyesh Agrawal, Leila B Giron, Shalini Singh, Nel Jason Haw, Aaron R Goldman, Mohamed Elkaeid, Bernard Macatangay, Frank J Palella, Maria L Alcaide, Caitlin A Moran and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Priyesh AgrawalAdaptive Phage Therapeutics, Gaithersburg, Maryland, USA.
Leila B GironThe Wistar Institute, Philadelphia, Pennsylvania, USA.
Shalini SinghThe Wistar Institute, Philadelphia, Pennsylvania, USA.
Nel Jason HawDepartment of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.
Aaron R GoldmanThe Wistar Institute, Philadelphia, Pennsylvania, USA.
Mohamed ElkaeidThe Wistar Institute, Philadelphia, Pennsylvania, USA.
Bernard MacatangayDivision of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Frank J PalellaDepartment of Medicine, Northwestern University, Chicago, Illinois, USA.
Maria L AlcaideInfectious Diseases Research Unit, University of Miami Miller School of Medicine, Miami, Florida, USA.
Caitlin A MoranDivision of Infectious Diseases, Emory University, Atlanta, Georgia, USA.
Seble G KassayeDepartment of Medicine, Georgetown University, Washington, DC, USA.
Nathan ErdmannSchool of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Kara W ChewDepartment of Medicine, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-4865-4348
Michelle Floris-MooreSchool of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Aruna ChandranDepartment of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.
Michael H AugenbraunDepartment of Medicine, SUNY Downstate Health Sciences University, Brooklyn, New York, USA.
Anjali SharmaDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Clovis PalmerTulane National Primate Research Center, Covington, Louisiana, USA.
Alan L LandayDepartment of Medicine, Rush University, Chicago, Illinois, USA.
Michael J PelusoDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Ali KeshavarzianDepartment of Medicine, Rush University, Chicago, Illinois, USA.
Todd T BrownSchool of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Phyllis C TienDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Mohamed Abdel-MohsenThe Wistar Institute, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-9945-4314

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ronald G Collman · 1999 to 2026
$78.6M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Aaron Robert Goldman · 1985 to 2026
$75.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
SF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3M
Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8M
American Lung Associationat TNRPCBEAT-HIV Martin Delaney CollaboratoryNCATS NIH HHS KL2 TR001432NCATS NIH HHS TL1 TR001431NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR001409NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR003098NCI NIH HHS P30 CA010815NHLBI NIH HHS U01 HL146192NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146203NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146205NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146241NHLBI NIH HHS U01 HL146242NHLBI NIH HHS U01 HL146245NHLBI NIH HHS U01 HL146333NIAAA NIH HHS R01 AA029859NIAAA NIH HHS R24 AA026801NIAID NIH HHS K23 AI157875NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI045008NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI073961NIAID NIH HHS R01 AI165079NIAID NIH HHS R21 AI170166NIAID NIH HHS U01 AI037984NIA NIH HHS R01 AG062383NIDDK NIH HHS R01 DK123733NIH HHS P51 OD011104NIH HHS R01AA029859NIH HHS S10 OD023586NIMH NIH HHS P30 MH116867NINDS NIH HHS R01 NS117458Penn Center for AIDS Research P30 AI 045008 toto Cure HIV-1 Infection by Combination Immunotherapy 1UM1Al126620TUHS Auxiliary Endowment for Excellence
6 · The paper itself

Abstract

Host metabolic dysregulation, especially in tryptophan metabolism, is intricately linked to coronavirus disease 2019 (COVID-19) severity and its postacute sequelae (long COVID). People living with human immunodeficiency virus (HIV; PLWH) experience similar metabolic dysregulation and face an increased risk of developing long COVID. However, whether preexisting HIV-associated metabolic dysregulations contribute in predisposing PLWH to severe COVID-19 outcomes remains underexplored. Analyzing prepandemic samples from PLWH with documented postinfection outcomes, we found specific metabolic alterations, including increased tryptophan catabolism, predicting an elevated risk of severe COVID-19 and the incidence of long COVID. These alterations warrant further investigation for their potential prognostic and mechanistic significance in determining COVID-19 complications.

Indexed as

COVID-19HIV InfectionsSARS-CoV-2Severity of Illness IndexAdultFemaleHumansIncidenceMaleMiddle AgedPost-Acute COVID-19 SyndromeTryptophanTryptophanCOVID-19HIVlong COVIDmetabolitestryptophan

Identifiers

PMID39011957
PMCPMC12102488

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.