Evidence map›Paper›PMID 39011872›Full record

ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2025

Independent inheritance of cognition and bipolar disorder in a family sample.

Alexander D'Amico, Heejong Sung, Alejandro Arbona-Lampaya, Ally Freifeld, Katie Hosey, Joshua Garcia, Ley Lacbawan, Emily Besançon, Layla Kassem, Nirmala Akula and 3 more

Abstract read
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In one paragraph

Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexander D'AmicoIntramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA.ORCID 0009-0006-5824-8035
Heejong SungIntramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA.
Alejandro Arbona-LampayaIntramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA.
Ally FreifeldIntramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA.
Katie HoseyIntramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA.
Joshua GarciaIntramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA.
Ley LacbawanIntramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA.
Emily BesançonIntramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA.
Layla KassemIntramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA.
Nirmala AkulaIntramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA.
Emma E M KnowlesHarvard Medical School, Boston, Massachusetts, USA.
Dwight DickinsonIntramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA.
Francis J McMahonIntramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA.

Funding

Identification of Genes Involved in Major Mood DisordersZIAMH002843 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$24.5M
A Collaborative Genomic Study of Bipolar DisorderZ01MH002842 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2004 to 2008
$1.2M
Intramural NIH HHS Z01 MH002842Intramural NIH HHS ZIA MH002843NIMH Intramural Research Program 1ZIAMH002843
6 · The paper itself

Abstract

Cognitive deficits in people with bipolar disorder (BD) may be the result of the illness or its treatment, but they could also reflect genetic risk factors shared between BD and cognition. We investigated this question using empirical genetic relationships within a sample of patients with BD and their unaffected relatives. Participants with bipolar I, II, or schizoaffective disorder ("narrow" BD, n = 69), related mood disorders ("broad" BD, n = 135), and their clinically unaffected relatives (n = 227) completed five cognitive tests. General cognitive function (g) was quantified via principal components analysis (PCA). Heritability and genetic correlations were estimated with SOLAR-Eclipse. Participants with "narrow" or "broad" diagnoses showed deficits in g, although affect recognition was unimpaired. Cognitive performance was significantly heritable (h

Indexed as

Bipolar DisorderCognitionFamilyAdultCognition DisordersFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedNeuropsychological TestsPsychotic DisordersbipolarcognitiongeneticsheritabilitySOLAR

Identifiers

PMID39011872
PMCPMC12088826

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.