Evidence map›Paper›PMID 39011855›Full record

Trial reportAging cell2024

Rapid benefits in older age from transition to whole food diet regardless of protein source or fat to carbohydrate ratio: Arandomised control trial.

Rosilene V Ribeiro, Alistair M Senior, Stephen J Simpson, Jian Tan, David Raubenheimer, David Le Couteur, Laurence Macia, Andrew Holmes, Joerg Eberhard, John O'Sullivan and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Aging cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rosilene V RibeiroSchool of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-8312-185X
Alistair M SeniorSchool of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
Stephen J SimpsonSchool of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
Jian TanCharles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
David RaubenheimerSchool of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
David Le CouteurCharles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Laurence MaciaCharles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Andrew HolmesCharles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Joerg EberhardCharles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
John O'SullivanCardiometabolic Medicine, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Yen Chin KoayCardiometabolic Medicine, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Alisar KanjrawiSchool of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
Jean YangCharles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Taiyun KimCharles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Alison GosbySchool of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.

Funding

Australian Research Council LP160100627
6 · The paper itself

Abstract

Plant-based diets reduces the risk of chronic conditions. The interaction between protein source and other macronutrients-fat (F) and carbohydrate (C)-has yet to be investigated. The aim was to assess the main and interactive effects of protein-source (plant vs. animal) and F:C (high or low) and the transition from an Australian diet to a whole food diet on various health markers in older individuals. This single-blinded, parallel, randomised experimental trial used a 2 × 2 factorial design to compare pro-vegetarian (70:30 plant to animal) versus omnivorous (50:50 plant to animal) diets at 14% protein and varying fat-to-carbohydrate ratios (high fat ~40% vs. low fat ~30%) over 4 weeks. Study foods were provided, alcohol consumption was discouraged, and dietary intake was determined through food records. Analysis included both RCT and observational data. Changes in appetite, palatability of diets, and dietary intake were assessed. Body composition, muscle strength, function, gut microbiome, and cardiometabolic health parameters were measured. Data from 113 (of the 128 randomised) individuals aged 65-75 years were analysed. Pro-vegetarian diets reduced diastolic blood pressure, total cholesterol and glucose levels. Moreover, the overall sample exhibited increased short-chain fatty acids and FGF21 levels, as well as improvements in body composition, function, and cardio-metabolic parameters irrespective of dietary treatment. Transitioning to a diet rich in fruit, vegetables, fibre, and moderate protein was associated with improved health markers in older age, with added benefits from pro-vegetarian diets. Further research on long-term effects is needed.

Indexed as

Dietary FatsDietary ProteinsAgedDietDietary CarbohydratesDiet, VegetarianFemaleHumansMaleDietary CarbohydratesDietary FatsDietary Proteinsagedappetitedietary carbohydratedietary fatsplant proteins

Identifiers

PMID39011855
PMCPMC11561649

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.