Evidence map›Paper›PMID 39011637›Full record

ArticleAge and ageing2024

The electronic frailty index and outcomes in patients with myocardial infarction.

Matthew T H Lowry, Dorien M Kimenai, Dimitrios Doudesis, Konstantin Georgiev, Michael McDermott, Anda Bularga, Caelan Taggart, Ryan Wereski, Amy V Ferry, Stacey D Stewart and 4 more

Abstract read
In one paragraph

Article in Age and ageing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. ANP Increases ZnCurrent medical science · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Matthew T H LowryBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-8972-5136
Dorien M KimenaiBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Dimitrios DoudesisBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Konstantin GeorgievBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Michael McDermottBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Anda BulargaBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Caelan TaggartBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Ryan WereskiBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Amy V FerryBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Stacey D StewartBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Christopher TuckBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
David E NewbyBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Nicholas L MillsBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Atul AnandBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-6428-4554

Funding

AORTIC PROTEOGLYCANS AND ATHEROSCLEROSISR01HL025161 · NHLBI · WAKE FOREST UNIVERSITY · PI WAGNER, WILLIAM D · 1986 to 1996
–
British Heart Foundation CH/09/002/26360British Heart Foundation CH/F/21/90010British Heart Foundation Clinical Research Training Fellowship FS/CRTF/21/2473British Heart Foundation Intermediate Basic Science Research Fellowship FS/IBSRF/23/25161British Heart Foundation through Chair CH/F/21/90010 and CH/09/002Clinical Research Training Fellowship MR/V007017/1Clinical Research Training Fellowships from the Medical Research Council MR/W000598/1Programme Grant RG/20/10/34966 and RG/F/22/110093Research Excellence Awards RE/18/5/34216
6 · The paper itself

Abstract

backgroundFrailty is increasingly present in patients with acute myocardial infarction. The electronic Frailty Index (eFI) is a validated method of identifying vulnerable older patients in the community from routine primary care data. Our aim was to assess the relationship between the eFI and outcomes in older patients hospitalised with acute myocardial infarction. STUDY DESIGN AND

settingRetrospective cohort study using the DataLoch Heart Disease Registry comprising consecutive patients aged 65 years or over hospitalised with a myocardial infarction between October 2013 and March 2021.

methodsPatients were classified as fit, mild, moderate, or severely frail based on their eFI score. Cox-regression analysis was used to determine the association between frailty category and all-cause mortality.

resultsIn 4670 patients (median age 77 years [71-84], 43% female), 1865 (40%) were classified as fit, with 1699 (36%), 798 (17%) and 308 (7%) classified as mild, moderate and severely frail, respectively. In total, 1142 patients died within 12 months of which 248 (13%) and 147 (48%) were classified as fit and severely frail, respectively. After adjustment, any degree of frailty was associated with an increased risk of all-cause death with the risk greatest in the severely frail (reference = fit, adjusted hazard ratio 2.87 [95% confidence intervals 2.24 to 3.66]).

conclusionThe eFI identified patients at high risk of death following myocardial infarction. Automatic calculation within administrative data is feasible and could provide a low-cost method of identifying vulnerable older patients on hospital presentation.

Indexed as

Frail ElderlyFrailtyGeriatric AssessmentMyocardial InfarctionAgedAged, 80 and overCause of DeathFemaleHospitalizationHumansMaleRegistriesRetrospective StudiesRisk AssessmentRisk Factorselectronic frailty indexfrailtymyocardial infarctionolder peopleroutine data

Identifiers

PMID39011637
PMCPMC11249914

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.