Evidence map›Paper›PMID 39011360›Full record

ArticleFrontiers in neurology2024

The National Institutes of Health Stroke Scale is comparable to the ICH score in predicting outcomes in spontaneous acute intracerebral hemorrhage.

Suzie A Kazaryan, Kristina Shkirkova, Jeffrey L Saver, David S Liebeskind, Sidney Starkman, Sebina Bulic, Roy Poblete, May Kim-Tenser, Shujing Guo, Robin Conwit and 3 more

Abstract read
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In one paragraph

Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Early neurological improvement with deferoxamine after intracerebral hemorrhage: A post hoc analysis of the i-DEF trial.International journal of stroke : official journal of the International Stroke Society · 2025
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Suzie A KazaryanRoxanna Todd Hodges Comprehensive Stroke Program, Department of Neurology, University of Southern California, Los Angeles, CA, United States.
Kristina ShkirkovaRoxanna Todd Hodges Comprehensive Stroke Program, Department of Neurology, University of Southern California, Los Angeles, CA, United States.
Jeffrey L SaverComprehensive Stroke Center and Department of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
David S LiebeskindComprehensive Stroke Center and Department of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
Sidney StarkmanComprehensive Stroke Center and Department of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
Sebina BulicRoxanna Todd Hodges Comprehensive Stroke Program, Department of Neurology, University of Southern California, Los Angeles, CA, United States.
Roy PobleteRoxanna Todd Hodges Comprehensive Stroke Program, Department of Neurology, University of Southern California, Los Angeles, CA, United States.
May Kim-TenserRoxanna Todd Hodges Comprehensive Stroke Program, Department of Neurology, University of Southern California, Los Angeles, CA, United States.
Shujing GuoComprehensive Stroke Center and Department of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
Robin ConwitNational Institutes of Health, Bethesda, MD, United States.
Pablo VillablancaComprehensive Stroke Center and Department of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
Scott HamiltonDepartment of Neurology, Stanford University, Stanford, CA, United States.
Nerses SanossianRoxanna Todd Hodges Comprehensive Stroke Program, Department of Neurology, University of Southern California, Los Angeles, CA, United States.

Funding

Field Administration of Stroke Therapy-Magnesium Trial (FAST-MAG)U01NS044364 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAVER, JEFFREY L · 2003 to 2013
$46.4M
NINDS NIH HHS U01 NS044364
6 · The paper itself

Abstract

Background: Validating the National Institutes of Health NIH Stroke Scale (NIHSS) as a tool to assess deficit severity and prognosis in patients with acute intracerebral hemorrhage would harmonize the assessment of intracerebral hemorrhage (ICH) and acute ischemic stroke (AIS) patients, enable clinical use of a readily implementable and non-imaging dependent prognostic tool, and improve monitoring of ICH care quality in administrative datasets. Methods: Among randomized trial ICH patients, the relation between NIHSS scores early after Emergency Department arrival and 3-month outcomes of dependency or death (modified Rankin Scale, mRS 3-6) and case fatality was examined. NIHSS predictive performance was compared to a current standard prognostic scale, the intracerebral hemorrhage score (ICH score). Results: Among the 384 patients, the mean age was 65 (±13), with 66% being male. The median NIHSS score was 16 (interquartile range (IQR) 9-25), the mean initial hematoma volume was 29 mL (±38), and the ICH score median was 1 (IQR 0-2). At 3 months, the mRS had a median of 4 (IQR 2-6), with dependency or death occurring in 70% and case fatality in 26%. The NIHSS and ICH scores were strongly correlated ( Conclusion: The NIHSS forecasts 3-month functional and case fatality outcomes with accuracy comparable to the ICH Score. Widely documented in routine clinical care and administrative data, the NIHSS can serve as a valuable measure for clinical prognostication, therapy development, and case-mix risk adjustment in ICH patients.

Indexed as

clinical trialclinimetricsintracerebral hemorrhageNIHSSprognosis

Identifiers

PMID39011360
PMCPMC11246900

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.