ArticleHemaSphere2024
Recommendations for diagnosis, treatment, and prevention of iron deficiency and iron deficiency anemia.
Article in HemaSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence and associated factors of anemia among newborns in Africa: a systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Efficacy, Safety, and Tolerability of Ferric Carboxymaltose and Iron Sucrose in Iron-Deficiency Anemia: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsTurkish journal of haematology : official journal of Turkish Society of Haematology · 2025Pooled it
- Safety and Efficacy of Oral Ferric Maltol and Ferrous Sulfate for Iron Deficiency Anemia in Infants, Children and Adolescents: A Multicenter Randomized Trial.Paediatric drugs · 2026Trial
- A Randomized, Open-Label, Single-Dose, Parallel-Group Bioequivalence Study of Ferric Carboxymaltose Injection Under Fasting Conditions in Chinese Adult Subjects With Iron Deficiency Anemia.Pharmacology research & perspectives · 2025Trial
- EHA Guidelines on the management of children and adults with hemoglobin SC disease.HemaSphere · 2026Article
- Biofortification ofFood science & nutrition · 2026Article
- Cost-effectiveness of iron deficiency screening in pregnancy across ferritin-based thresholds.Blood advances · 2026Article
- An ironclad case for cost-effective screening in pregnancy.Blood advances · 2026Article
- Article
- Factors Associated with Delayed Diagnosis of Iron Deficiency Anemia in Egyptian Patients: A Retrospective Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- Review
- Physiologically based ferritin thresholds to redefine early pregnancy iron screening: a cross-sectional study.Scientific reports · 2026Article
- The interplay between cytokine genes and microRNAs in anemia of inflammation among hemodialysis patients.Scientific reports · 2026Article
- Iron Deficiency and Oral Treatments: Limitations, Pharmacokinetics, and the Role of Iron Protein Succinylate in Clinical Practice.Journal of clinical medicine · 2026Review
- The real diagnostic value of serum iron in iron deficiency anemia among patients with inflammatory bowel disease: A retrospective study.The Journal of international medical research · 2026Article
- Article
- Individual and Community-Level Predictors of Anemia in Chicago-Area Pregnancies: A Multi-Level Analysis of Electronic Health Record Data.Birth (Berkeley, Calif.) · 2026Article
- Iron Therapy in Pediatric Iron Deficiency and Iron-Deficiency Anemia: Efficacy, Safety, and Formulation-Specific Trade-Offs-A Narrative Review.Hematology reports · 2026Review
- Anemia, iron deficiency, and blood biomarkers for Alzheimer disease: clinical interpretation and dementia risk stratification.Frontiers in nutrition · 2026Review
- High proportions of iron deficiency and thalassemia in blood donors with low RBC osmotic fragility: a call for targeted public health responses in Southern China.Frontiers in public health · 2026Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron is an essential nutrient and a constituent of ferroproteins and enzymes crucial for human life. Generally, nonmenstruating individuals preserve iron very efficiently, losing less than 0.1% of their body iron content each day, an amount that is replaced through dietary iron absorption. Most of the iron is in the hemoglobin (Hb) of red blood cells (RBCs); thus, blood loss is the most common cause of acute iron depletion and anemia worldwide, and reduced hemoglobin synthesis and anemia are the most common consequences of low plasma iron concentrations. The term iron deficiency (ID) refers to the reduction of total body iron stores due to impaired nutrition, reduced absorption secondary to gastrointestinal conditions, increased blood loss, and increased needs as in pregnancy. Iron deficiency anemia (IDA) is defined as low Hb or hematocrit associated with microcytic and hypochromic erythrocytes and low RBC count due to iron deficiency. IDA most commonly affects women of reproductive age, the developing fetus, children, patients with chronic and inflammatory diseases, and the elderly. IDA is the most frequent hematological disorder in children, with an incidence in industrialized countries of 20.1% between 0 and 4 years of age and 5.9% between 5 and 14 years (39% and 48.1% in developing countries). The diagnosis, management, and treatment of patients with ID and IDA change depending on age and gender and during pregnancy. We herein summarize what is known about the diagnosis, treatment, and prevention of ID and IDA and formulate a specific set of recommendations on this topic.
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Registered trials
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