ArticleResearch square2024
Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity.
Shuhan Huang, Daniella Rizzo, Sherry Jingjing Wu, Qing Xu, Leena Ziane, Norah Alghamdi, David A Stafford, Tanya L Daigle, Bosiljka Tasic, Hongkui Zeng and 2 more
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In one paragraphArticle in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Shuhan HuangHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.ORCID 0000-0002-3139-7296 Daniella RizzoHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.
Sherry Jingjing WuHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.
Qing XuBiological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Kingdom of Saudi Arabia.ORCID 0000-0001-9479-470X Leena ZianeHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.
Norah AlghamdiBiological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Kingdom of Saudi Arabia.
David A StaffordDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94708, USA.
Tanya L DaigleAllen Institute for Brain Science, Seattle, WA 98109, USA.
Leena Ali IbrahimBiological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Gord FishellHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.ORCID 0000-0002-9640-9278 Funding
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6 · The paper itselfAbstract
Neurogliaform cells are a distinct type of GABAergic cortical interneurons known for their 'volume transmission' output property. However, their activity and function within cortical circuits remain unclear. Here, we developed two genetic tools to target these neurons and examine their function in the primary visual cortex. We found that the spontaneous activity of neurogliaform cells positively correlated with locomotion. Silencing these neurons increased spontaneous activity during locomotion and impaired visual responses in L2/3 pyramidal neurons. Furthermore, the contrast-dependent visual response of neurogliaform cells varies with their laminar location and is constrained by their morphology and input connectivity. These findings demonstrate the importance of neurogliaform cells in regulating cortical behavioral state-dependent spontaneous activity and indicate that their functional engagement during visual stimuli is influenced by their laminar positioning and connectivity.
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PMID39011116
PMCPMC11247929
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