Evidence map›Paper›PMID 39011088›Full record

ArticleFrontiers in physiology2024

Cardiomyocyte crosstalk with endothelium modulates cardiac structure, function, and ischemia-reperfusion injury susceptibility through erythropoietin.

Jade P Marrow, Razan Alshamali, Brittany A Edgett, Melissa A Allwood, Kyla L S Cochrane, Sara Al-Sabbag, Anmar Ayoub, Kjetil Ask, Gregory M T Hare, Keith R Brunt and 1 more

Abstract read
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In one paragraph

Article in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jade P Marrow *Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Razan Alshamali *Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Brittany A EdgettDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Melissa A AllwoodDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Kyla L S CochraneDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Sara Al-SabbagDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Anmar AyoubFirestone Institute for Respiratory Health, McMaster University, Hamilton, ON, Canada.
Kjetil AskFirestone Institute for Respiratory Health, McMaster University, Hamilton, ON, Canada.
Gregory M T HareIMPART Investigator Team Canada, Guelph, ON, Canada.
Keith R BruntIMPART Investigator Team Canada, Guelph, ON, Canada.
Jeremy A SimpsonDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erythropoietin (EPO) exerts non-canonical roles beyond erythropoiesis that are developmentally, structurally, and physiologically relevant for the heart as a paracrine factor. The role for paracrine EPO signalling and cellular crosstalk in the adult is uncertain. Here, we provided novel evidence showing cardiomyocyte restricted loss of function in

Indexed as

compensationCre-LoxEPAS1 geneerythropoiesiserythropoietinhemodynamicsvascular endothelial growth factor

Identifiers

PMID39011088
PMCPMC11246973

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.