Evidence map›Paper›PMID 39010981›Full record

ArticleEClinicalMedicine2024

Projecting the clinical burden of chronic kidney disease at the patient level (

Glenn M Chertow, Ricardo Correa-Rotter, Kai-Uwe Eckardt, Eiichiro Kanda, Avraham Karasik, Guisen Li, Christian Fynbo Christiansen, Panos Stafylas, Stephen G Holt, Ernst C Hagen and 7 more

Abstract read
In one paragraph

Article in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Chronic PMScientific reports · 2026
    Article
  10. Article
  11. International Environmental Impact of CKD Care.Kidney international reports · 2026
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. "Kidney international reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Glenn M ChertowStanford University School of Medicine, Stanford Palo Alto, CA 94305, USA.
Ricardo Correa-RotterInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
Kai-Uwe EckardtDepartment of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin 10117, Germany.
Eiichiro KandaMedical Science, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan.
Avraham KarasikMaccabi Institute for Research and Innovation, Maccabi Healthcare Services, Tel Aviv 68125, Israel.
Guisen LiDepartment of Nephrology and Institute of Nephrology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Sichuan Clinical Research Centre for Kidney Diseases, Chengdu 610072, China.
Christian Fynbo ChristiansenDepartment of Clinical Epidemiology, Aarhus University Hospital and Aarhus University, Olof Palmes Allé 43-45, Aarhus N DK-8200, Denmark.
Panos StafylasHealThink, THERMI GROUP, Steliou Kazantzidi 47 str., Building 1, PC 57 001, PO Box 8121, Thessaloniki, Greece.
Stephen G HoltSEHA Kidney Care, SKC Central, Abu Dhabi Health Services Co., Al Himam St, Al Mafraq, Abu Dhabi, United Arab Emirates.
Ernst C HagenMeander Medical Center, Maatweg 3, Amersfoort 3813 TZ, Netherlands.
Juan Jose Garcia SanchezGlobal Health Economics, BioPharmaceuticals, AstraZeneca, Academy House, 136 Hills Road, Cambridge CB2 8PA, UK.
Salvatore BaroneGlobal Medical Affairs, BioPharmaceuticals, AstraZeneca, Gaithersburg, MD 20878, USA.
Claudia CabreraReal World Science and Analytics, BioPharmaceuticals Medical, AstraZeneca, Gothenburg SE-431 83, Sweden.
Stephen NolanGlobal Medical Affairs, BioPharmaceuticals Medical, AstraZeneca, Cambridge CB2 0AA, UK.
Timothy CokerHealthLumen Limited, London EC3N 2PJ, UK.
Laura WebberHealthLumen Limited, London EC3N 2PJ, UK.
Lise RetatHealthLumen Limited, London EC3N 2PJ, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic kidney disease (CKD) is a global concern that presents significant challenges for disease management. Several factors drive CKD prevalence, including primary risk factors, such as type 2 diabetes and hypertension, and an ageing population. Methods: Using a peer-reviewed microsimulation method, the clinical burden of CKD was estimated from 2022 to 2027. Demographic data from the Americas, Europe, and Asia-Pacific/Middle East were used to generate virtual populations and to project the prevalence of CKD, kidney replacement therapy, associated cardiovascular complications, comorbid conditions, and all-cause mortality in the CKD population over the modelled time frame. Findings: Across the 31 participating countries/regions, the total prevalence of CKD was projected to rise to 436.6 million cases by 2027 (an increase of 5.8% from 2022), with most cases (∼80%) undiagnosed. Interpretation: The clinical impact of CKD is substantial and likely to increase; the high prevalence of undiagnosed cases and associated complications may benefit from the implementation of health policy interventions that promote screening, earlier diagnosis, and interventions to improve outcomes. Funding: AstraZeneca.

Indexed as

Burden of diseaseChronic kidney diseaseEpidemiologyMicrosimulationPolicy

Identifiers

PMID39010981
PMCPMC11247147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.