Evidence map›Paper›PMID 39010872›Full record

ArticleArXiv2024

Biophysical effects and neuromodulatory dose of transcranial ultrasonic stimulation.

Tulika Nandi, Benjamin R Kop, Kasra Naftchi-Ardebili, Charlotte J Stagg, Kim Butts Pauly, Lennart Verhagen

Abstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Tulika NandiDonders Institute for Brain Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Benjamin R KopDonders Institute for Brain Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Kasra Naftchi-ArdebiliDepartment of Radiology, Stanford University, Stanford, CA, USA.
Charlotte J StaggWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Kim Butts PaulyDepartment of Radiology, Stanford University, Stanford, CA, USA.
Lennart VerhagenDonders Institute for Brain Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.

Funding

Neurostimulation by Ultrasound: Physical, Biophysical, and Neural MechanismsR01NS112152 · NINDS · STANFORD UNIVERSITY · PI BACCUS, STEPHEN A, BUTTS-PAULY, KIM · 2020 to 2024
$4.9M
Step 1 in Designing Appropriate Shams and Controls in Human TUSR01MH131684 · NIMH · STANFORD UNIVERSITY · PI Kim Butts Pauly · 2023 to 2026
$2.6M
CRCNS: Crossbeam Transcranial Ultrasound Technology to Stimulate the Deep BrainR01EB032743 · NIBIB · STANFORD UNIVERSITY · PI BUTTS-PAULY, KIM · 2021 to 2023
$520k
NIBIB NIH HHS R01 EB032743NIMH NIH HHS R01 MH131684NINDS NIH HHS R01 NS112152Wellcome Trust
6 · The paper itself

Abstract

Transcranial ultrasonic stimulation (TUS) has the potential to usher in a new era for human neuroscience by allowing spatially precise and high-resolution non-invasive targeting of both deep and superficial brain regions. Currently, fundamental research on the mechanisms of interaction between ultrasound and neural tissues is progressing in parallel with application-focused research. However, a major hurdle in the wider use of TUS is the selection of optimal parameters to enable safe and effective neuromodulation in humans. In this paper, we will discuss the major factors that determine both the safety and efficacy of TUS. We will discuss the thermal and mechanical biophysical effects of ultrasound, which underlie its biological effects, in the context of their relationships with tunable parameters. Based on this knowledge of biophysical effects, and drawing on concepts from radiotherapy, we propose a framework for conceptualising TUS dose.

Identifiers

PMID39010872
PMCPMC11247917

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.