Evidence map›Paper›PMID 39010690›Full record

ArticleBrain and behavior2024

High baseline perivascular space volume in basal ganglia is associated with attention and executive function decline in Parkinson's disease.

Ryan Patrick Foreman, Erin Kaye Donahue, Jared Joshua Duran, Dawn M Schiehser, Andrew Petkus, Joseph O'Neill, Daniel Phillip Holschneider, Jeiran Choupan, John Darrell Van Horn, Ece Bayram and 3 more

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In one paragraph

Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ryan Patrick ForemanDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Erin Kaye DonahueDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-2342-5015
Jared Joshua DuranDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Dawn M SchiehserVeterans Administration San Diego Healthcare System (VASDHS), San Diego, California, USA.
Andrew PetkusDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Joseph O'NeillDepartment of Psychiatry & the Behavioral Sciences, University of Southern California, Los Angeles, California, USA.
Daniel Phillip HolschneiderDivision of Child Psychiatry, UCLA Semel Institute for Neuroscience, Los Angeles, California, USA.
Jeiran ChoupanLaboratory of NeuroImaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
John Darrell Van HornSchool of Data Science, University of Virginia, Charlottesville, Virginia, USA.
Ece BayramParkinson and Other Movement Disorder Center, Department of Neurosciences, University of California, San Diego, San Diego, California, USA.
Irene LitvanParkinson and Other Movement Disorder Center, Department of Neurosciences, University of California, San Diego, San Diego, California, USA.
Michael Walter JakowecAlfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California, USA.
Giselle Maria PetzingerDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Funding

Kirk Hyde and Angie ProctorThe Parkinson's FoundationUS Department of Defense (U.S. Army, CDMRP) #W81XWH18-1-0665 (GP)US Department of Defense (U.S. Army, CDMRP) #W81XWH181-0666 (DPH)US Department of Defense (U.S. Army, CDMRP) W81XWH19-1-0443 (MWJ)
6 · The paper itself

Abstract

backgroundPathologic perivascular spaces (PVS), the fluid-filled compartments surrounding brain vasculature, may underlie cognitive decline in Parkinson's disease (PD). However, whether this impacts specific cognitive domains has not been investigated.

objectivesThis study examined the relationship of PVS volume at baseline with domain-specific and global cognitive change over 2 years in PD individuals.

methodsA total of 39 individuals with PD underwent 3T T1w magnetic resonance imaging to determine PVS volume fraction (PVS volume normalized to total regional volume) within (i) centrum semiovale, (ii) prefrontal white matter (medial orbitofrontal, rostral middle frontal, and superior frontal), and (iii) basal ganglia. A neuropsychological battery included assessment of cognitive domains and global cognitive function at baseline and after 2 years.

resultsHigher basal ganglia PVS at baseline was associated with greater decline in attention, executive function, and global cognition scores.

conclusionsWhile previous reports have associated elevated PVS volume in the basal ganglia with decline in global cognition in PD, our findings show such decline may affect the attention and executive function domains.

Indexed as

AttentionBasal GangliaCognitive DysfunctionExecutive FunctionMagnetic Resonance ImagingParkinson DiseaseAgedFemaleGlymphatic SystemHumansMaleMiddle AgedNeuropsychological TestsWhite MatterVirchow–Robinson space

Identifiers

PMID39010690
PMCPMC11250171

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.