Evidence map›Paper›PMID 39010324›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2024

Evaluation of oral herpes simplex virus shedding among solid organ transplant recipients: A pilot study.

Molly D Fischer, Margaret L Green, Stacy Selke, Ajit P Limaye, Anna Wald, Michael J Boeckh, Amanda I Phipps, Steven A Pergam, Christine Johnston

Abstract read
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In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Molly D FischerDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-5147-5909
Margaret L GreenDepartment of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
Stacy SelkeDepartments of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
Ajit P LimayeDepartment of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
Anna WaldDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Michael J BoeckhDepartment of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
Amanda I PhippsDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Steven A PergamDepartment of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-6333-5196
Christine JohnstonDepartment of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.

Funding

HOST DEFENSE TRAINING IN ALLERGY AND INFECTIOUS DISEASEST32AI007044 · NIAID · UNIVERSITY OF WASHINGTON · PI DAVID Neal FREDRICKS · 1985 to 2026
$14.6M
CMV Entry-Specific Neutralizing Antibody in Primary Infection in TransplantationK23AI097234 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GREEN, MARGARET L · 2012 to 2016
$653k
National Institute of Allergy and Infectious Diseases K-23AI097234National Institute of Allergy and Infectious Diseases T32 AI 007044NIAID NIH HHS K23 AI097234NIAID NIH HHS T32 AI007044
6 · The paper itself

Abstract

backgroundHerpes simplex viruses (HSVs) frequently reactivate during immunosuppression and may be a risk factor for adverse outcomes after solid organ transplant (SOT). While suppressive antiviral therapy reduces the risk of symptomatic HSV reactivation, the kinetics of asymptomatic viral shedding with chronic immunosuppression after transplant are not well understood. We report the characteristics of oral HSV shedding among 15 HSV-1 seropositive SOT recipients (n = 8 liver, n = 7 kidney, median age 58.5 years, median 20 months post-transplant) who were not taking daily antiviral suppressive therapy.

methodsParticipants self-collected oral swabs three times daily for 6 weeks for HSV quantification and recorded the presence of oral symptoms or lesions in a diary.

resultsSample collection adherence was high (median 122 swabs/person, range: 85.7%-101.6% of expected swabs). Most participants (n = 12, 80%) experienced at least one shedding episode, with a median shedding rate of 8.9% (range: 0%-33.6%). There were 32 total shedding episodes, 24 (75%) of which occurred without symptoms or lesions. For episodes of known duration, the median length was 21.8 hrs (interquartile range: 10.8-46.1 hrs).

conclusionMost shedding episodes (78.1%) lasted >12 hrs, suggesting that twice-daily sampling may be sufficient to detect most episodes. These data show that self-collection of oral swabs is feasible for patients who have undergone SOTs and can provide insight into the frequency of oral HSV reactivation, which can be used to design future studies in this population.

Indexed as

Herpesvirus 1, HumanTransplant RecipientsVirus SheddingAdultAgedFemaleHerpes SimplexHumansImmunosuppression TherapyKidney TransplantationLiver TransplantationMaleMiddle AgedOrgan TransplantationPilot ProjectsVirus Activation

Identifiers

PMID39010324
PMCPMC11329158

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.