Evidence map›Paper›PMID 39010232›Full record

ArticleTrials2024

Prenatal affective cognitive training to reduce the risk of postpartum depression (PACT): study protocol for a randomized controlled trial.

Anne J Bjertrup, Jeanne Kofoed, Ida Egmose, Katrine Wendelboe, Victoria Southgate, Mette S Væver, Kamilla W Miskowiak

2 registry-linked trialsAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06046456 naunknown statusnot on this map

Prenatal Affective Cognitive Training to Reduce the Risk of Postpartum Depression (PACT): Study Protocol for a Randomized Controlled Trial

TypeinterventionalSponsorMental Health Centre Copenhagen, Bispebjerg and Frederiksberg HospitalRan2023 to 2025Enrolled146ConditionsPostpartum Depression, Emotional Regulation, Cognitive Function 1, Social, Pregnancy RelatedArmsPrenatal Affective CogntiiveTraining
NCT07302165 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

PreParent: Internet-based Digital Tools to Screen for and Prevent Postpartum Depression in Parents-to-be: Identifying and Targeting Cognitive Risk Factors

TypeinterventionalSponsorMental Health Centre Copenhagen, Bispebjerg and Frederiksberg HospitalRan2025 to 2027Enrolled520ConditionsPost-partum DepressionArmsOnline prenatal affective cognitive training
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anne J BjertrupThe Neurocognition and Emotion in Affective Disorders Centre (NEAD), Psychiatric Centre Copenhagen, Mental Health Services in the Capital Region of Denmark, Frederiksberg, Denmark. anne.juul.bjertrup@regionh.dk.ORCID http://orcid.org/0000-0002-2726-9777
Jeanne KofoedThe Neurocognition and Emotion in Affective Disorders Centre (NEAD), Psychiatric Centre Copenhagen, Mental Health Services in the Capital Region of Denmark, Frederiksberg, Denmark.
Ida EgmoseDepartment of Psychology, Faculty of Social Sciences, University of Copenhagen, Copenhagen, Denmark.
Katrine WendelboeDepartment of Psychology, Faculty of Social Sciences, University of Copenhagen, Copenhagen, Denmark.
Victoria SouthgateDepartment of Psychology, Faculty of Social Sciences, University of Copenhagen, Copenhagen, Denmark.
Mette S VæverDepartment of Psychology, Faculty of Social Sciences, University of Copenhagen, Copenhagen, Denmark.
Kamilla W MiskowiakThe Neurocognition and Emotion in Affective Disorders Centre (NEAD), Psychiatric Centre Copenhagen, Mental Health Services in the Capital Region of Denmark, Frederiksberg, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostpartum depression (PPD) affects 30-50% of women with a history of previous depression or bipolar disorder and 8% of women with no history of depression. Negative cognitive biases in the perception of infant cues and difficulties with emotion regulation are replicated risk factors. Current interventions focus on detecting and treating rather than preventing PPD. The aim of this randomized controlled intervention trial is therefore to investigate the potential prophylactic effects of prenatal affective cognitive training for pregnant women at heightened risk of PPD.

methodsThe study will enrol a total of 292 pregnant women: 146 at high risk and 146 at low risk of PPD. Participants undergo comprehensive assessments of affective cognitive processing, clinical depressive symptoms, and complete questionnaires at baseline. Based on the responses, pregnant women will be categorized as either at high or low risk of PPD. High-risk participants will be randomized to either prenatal affective cognitive training (PACT) or care as usual (CAU) immediately after the baseline testing. The PACT intervention is based on emerging evidence for efficacy of affective cognitive training approaches in depression, including cognitive bias modification, attention bias modification, mindfulness-inspired emotion regulation exercises, and working memory training. Participants randomised to PACT will complete five individual computerised and virtual reality-based training sessions over 5 weeks. The primary outcome is the difference between intervention arms in the incidence of PPD, assessed with an interview 6 months after birth. We will also assess the severity of depressive symptoms, rated weekly online during the first 6 weeks postpartum. DISCUSSION: The results will have implications for future early prophylactic interventions for pregnant women at heightened risk of PPD. If the PACT intervention reduces the incidence of PPD, it can become a feasible, non-invasive prophylactic strategy during pregnancy, with positive mental health implications for these women and their children.

trial registrationClinicalTrials.gov NCT06046456 registered 21-09-2023, updated 08-07-2024.

Indexed as

Depression, PostpartumRandomized Controlled Trials as TopicAdultAffectCognitionCognitive Behavioral TherapyCognitive TrainingFemaleHumansPregnancyPrenatal CareRisk FactorsTreatment OutcomeAffective cognitive trainingAttention bias modificationCognitive bias modificationEmotion regulationHigh-risk pregnancyMother-infant relationsPostpartum depressionPreventionRandomized controlled trialWorking memory training

Identifiers

PMID39010232
PMCPMC11247870

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.