Evidence map›Paper›PMID 39010212›Full record

ArticleArchives of public health = Archives belges de sante publique2024

Medication nonadherence and associated factors in patients with tuberculosis in Wau, South Sudan: a cross- sectional study using the world health organization multidimensional adherence model.

Peter Michael Marin, Musso Munyeme, Clovice Kankya, Ambrose Samuel Jubara, Enock Matovu, Peter Waiswa, Javier Sanchez Romano, Francis Mutebi, David Onafruo, Estella Kitale and 3 more

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In one paragraph

Article in Archives of public health = Archives belges de sante publique, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Peter Michael MarinDepartment of Public Health, University of Bahr El Ghazal (UBG), Wau, South Sudan. pmarin999@gmail.com.
Musso MunyemeDepartment of Disease Control, University of Zambia, Lusaka, Zambia.
Clovice KankyaDepartment of Biosecurity, Ecosystem and Veterinary Public Health, Makerere University, Kampala, Uganda.
Ambrose Samuel JubaraDepartment of Clinical Studies, University of Bahr El Ghazal (UBG), Wau, South Sudan.
Enock MatovuDepartment of Bimolecular Resources and Biolab Sciences, Makerere University, Kampala, Uganda.
Peter WaiswaDepartment of Biosecurity, Ecosystem and Veterinary Public Health, Makerere University, Kampala, Uganda.
Javier Sanchez RomanoDepartment of Medical Biology, UiT-The Arctic University of Norway (UiT), Tromsø, Norway.
Francis MutebiDepartment of Pharmacy, Clinical and Comparative Medicine, Makerere University, Kampala, Uganda.
David OnafruoDepartment of Biosecurity, Ecosystem and Veterinary Public Health, Makerere University, Kampala, Uganda.
Estella KitaleDepartment of Biosecurity, Ecosystem and Veterinary Public Health, Makerere University, Kampala, Uganda.
Owori BenardClinical Epidemiology Unit, Makerere University, Kampala, Uganda.
Kayla J BuhlerDepartment of Forestry & Wildlife Management, Inland Norway University of Applied Sciences (INN), Evenstad, Norway.
Morten TrylandDepartment of Forestry & Wildlife Management, Inland Norway University of Applied Sciences (INN), Evenstad, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTuberculosis medication nonadherence is a multi-dimensional public health problem with serious consequences worldwide. There is little information available for medication nonadherence in South Sudan. This study assessed the proportion, reasons, and associated factors for nonadherence among patients with TB in Wau Municipality, South Sudan.

methodsA health facility based cross-sectional study was conducted among 234 tuberculosis (TB) patients receiving first line anti-TB regimen in Wau Municipality. Urine isoniazid metabolite testing (IsoScreen

resultsOut of 234 participants, 24.8% (95% CI, 19.2 - 30.3) were nonadherent to the TB treatment regimen. At multivariate analysis, nonadherence was significantly associated with: relief of symptoms (APR 1.93, 95% CI 1.12 - 3.34, p = 0.018), alcohol use (APR 2.12, 95% CI 1.33 - 3.96, p = 0.019) and waiting time to receive drugs (APR 1.77, 95% CI 1.11 - 2.83, p = 0.017).

conclusionTuberculosis medication nonadherence was high, and it's associated with patients' relived of symptoms, alcohol use, and prolonged waiting time at health facility. Hence, addressing these barriers and the use of multifaceted interventions e.g. counseling, health education and improve appointments are crucial to reduce nonadherence among patients with TB in South Sudan.

Indexed as

CounselingHealth educationMycobacterium tuberculosisPublic HealthUrine isoniazid testing

Identifiers

PMID39010212
PMCPMC11250949

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.