ArticleBMC biotechnology2024
Characterization of a thermostable protease from Bacillus subtilis BSP strain.
Article in BMC biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- High-level expression and characterization of a thermostable thermolysin-like metalloprotease with industrial potential.Folia microbiologica · 2026Article
- Production of Vitamin K2 Enriched Dairy Cream byFood science & nutrition · 2026Article
- Characterizing the role of an endogenous serine protease KpSub2 in recombinant collagen degradation in Komagataella phaffii.Bioresources and bioprocessing · 2026Article
- Proteolytic enzymes from Bacillus subtilis AB2 as antibiofilm adjuvants: Bioprocess optimization, mechanistic insights, and synergy with antibiotics.Journal of microbiology (Seoul, Korea) · 2025Article
- Purification and characterization of an extremely thermostable metalloprotease from Geobacillus thermoleovorans HBB208.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Membrane Vesicles ofMicroorganisms · 2025Article
- Comprehensive biochemical, molecular and structural characterization of subtilisin with fibrinolytic potential in bioprocessing.Bioresources and bioprocessing · 2025Article
- Extreme thermal environments: reservoirs of industrially important thermozymes.Frontiers in microbiology · 2025Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study used conservative one variable-at-a-time study and statistical surface response methods to increase the yields of an extracellular thermostable protease secreted by a newly identified thermophilic Bacillus subtilis BSP strain. Using conventional optimization techniques, physical parameters in submerged fermentation were adjusted at the shake flask level to reach 184 U/mL. These physicochemical parameters were further optimized by statistical surface response methodology using Box Behnken design, and the protease yield increased to 295 U/mL. The protease was purified and characterized biochemically. Both Ca
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