Evidence map›Paper›PMID 39009868›Full record

ReviewNature reviews. Immunology2024

How bile acids and the microbiota interact to shape host immunity.

Michael H Lee, Sean-Paul Nuccio, Ipsita Mohanty, Lee R Hagey, Pieter C Dorrestein, Hiutung Chu, Manuela Raffatellu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Bile acid signaling in health and disease.Molecular biomedicine · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Review
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  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael H LeeDivision of Host-Microbe Systems and Therapeutics, Department of Paediatrics, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3676-0306
Sean-Paul NuccioDivision of Host-Microbe Systems and Therapeutics, Department of Paediatrics, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9683-9278
Ipsita MohantySkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Lee R HageyDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3003-1030
Hiutung ChuCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7489-0446
Manuela RaffatelluDivision of Host-Microbe Systems and Therapeutics, Department of Paediatrics, University of California San Diego, La Jolla, CA, USA. manuelar@health.ucsd.edu.ORCID http://orcid.org/0000-0001-6487-4215

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bile acids are increasingly appearing in the spotlight owing to their novel impacts on various host processes. Similarly, there is growing attention on members of the microbiota that are responsible for bile acid modifications. With recent advances in technology enabling the discovery and continued identification of microbially conjugated bile acids, the chemical complexity of the bile acid landscape in the body is increasing at a rapid pace. In this Review, we summarize our current understanding of how bile acids and the gut microbiota interact to modulate immune responses during homeostasis and disease, with a particular focus on the gut.

Indexed as

Bile Acids and SaltsGastrointestinal MicrobiomeAnimalsHomeostasisHumansBile Acids and Salts

Identifiers

PMID39009868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.