Evidence map›Paper›PMID 39009856›Full record

ArticleNeuroradiology2024

Identification of prognostic imaging biomarkers in H3 K27-altered diffuse midline gliomas in adults: impact of tumor oxygenation imaging biomarkers on survival.

Yongsik Sim, Kaeum Choi, Kyunghwa Han, Seo Hee Choi, Narae Lee, Yae Won Park, Na-Young Shin, Sung Soo Ahn, Jong Hee Chang, Se Hoon Kim and 1 more

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Article in Neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yongsik SimDepartment of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.ORCID http://orcid.org/0000-0003-2711-2793
Kaeum ChoiDepartment of Statistics and Data Science, Yonsei University, Seoul, Korea.
Kyunghwa HanDepartment of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.ORCID http://orcid.org/0000-0002-5687-7237
Seo Hee ChoiDepartment of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0002-4083-6414
Narae LeeDepartment of Nuclear Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.ORCID http://orcid.org/0000-0002-0526-5708
Yae Won ParkDepartment of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea. yaewonpark@yuhs.ac.ORCID http://orcid.org/0000-0001-8907-5401
Na-Young ShinDepartment of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.ORCID http://orcid.org/0000-0003-1157-6366
Sung Soo AhnDepartment of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.ORCID http://orcid.org/0000-0002-0503-5558
Jong Hee ChangDepartment of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0003-1509-9800
Se Hoon KimDepartment of Pathology, Yonsei University College of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0001-7516-7372
Seung-Koo LeeDepartment of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.ORCID http://orcid.org/0000-0001-5646-4072

Funding

Ministry of Education 2020R1I1A1A01071648
6 · The paper itself

Abstract

purposeTo investigate prognostic markers for H3 K27-altered diffuse midline gliomas (DMGs) in adults with clinical, qualitative and quantitative imaging phenotypes, including tumor oxygenation characteristics.

methodsRetrospective chart and imaging reviews were conducted on 32 adults with H3 K27-altered DMGs between 2017 and 2023. Clinical and qualitative imaging characteristics were analyzed. Quantitative imaging assessment was performed from the tumor mask via automatic segmentation to calculate normalized cerebral blood volume (nCBV), capillary transit time heterogeneity (CTH), oxygen extraction fraction (OEF), relative cerebral metabolic rate of oxygen (rCMRO

resultsThe median patient age was 40.5 years (range 19.9-75.7), with an OS of 30.3 months (interquartile range 11.3-32.3). In entire patients, the presence of LM was the only independent predictor of OS (hazard ratio [HR] = 6.01, P = 0.009). In the subgroup of 23 (71.9%) patients with CE tumors, rCMRO

conclusionThe presence of LM was independently associated with poor prognosis in adult patients with H3 K27-altered DMG. In patients with CE tumors, higher rCMRO

Indexed as

Biomarkers, TumorBrain NeoplasmsGliomaAdultAgedContrast MediaFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateYoung AdultBiomarkers, TumorContrast MediaCerebral metabolic rate of oxygenDiffuse midline gliomaMagnetic resonance imagingSurvival analysis

Identifiers

PMID39009856

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.