Evidence map›Paper›PMID 39009838›Full record

ArticleNature immunology2024

BACH2 regulates diversification of regulatory and proinflammatory chromatin states in T

Pratiksha I Thakore, Alexandra Schnell, Linglin Huang, Maryann Zhao, Yu Hou, Elena Christian, Sarah Zaghouani, Chao Wang, Vasundhara Singh, Anvita Singaraju and 11 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
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  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Contextualizing TNature reviews. Immunology · 2026
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Pratiksha I Thakore *Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Alexandra Schnell *Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3442-7750
Linglin HuangThe Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Maryann ZhaoKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9325-4066
Yu HouKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Elena ChristianKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5593-0155
Sarah ZaghouaniThe Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4467-6542
Chao WangKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Vasundhara SinghKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8391-8527
Anvita SingarajuThe Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3109-6354
Rajesh Kumar KrishnanThe Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Deneen KozorizThe Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Sai MaKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-9785-7929
Venkat SankarKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Samuele NotarbartoloInstitute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0001-5910-4910
Jason D BuenrostroDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9958-3987
Federica SallustoInstitute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0003-3750-2752
Nikolaos A PatsopoulosSystems Biology and Computer Science Program, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham & Women's Hospital, Boston, MA, USA.
Orit Rozenblatt-RosenKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6313-3570
Vijay K KuchrooKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. vkuchroo@bwh.harvard.edu.ORCID http://orcid.org/0000-0001-7177-2110
Aviv RegevKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aviv.regev.sc@gmail.com.ORCID http://orcid.org/0000-0003-3293-3158

Funding

Role of Th1 specific cell surface molecule Tim-3 in EAE.R01NS045937 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI KUCHROO, VIJAY K. · 2003 to 2016
$4.9M
Role of Tim-3:Bat-3 pathway in inducing tolerogenic DCs and peripheral toleranceR01AI144166 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI VIJAY K. KUCHROO · 2020 to 2026
$3.2M
U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AI144166U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01NS045937U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01NS30843
6 · The paper itself

Abstract

Interleukin-17 (IL-17)-producing helper T (T

Indexed as

Basic-Leucine Zipper Transcription FactorsChromatinTh17 CellsAnimalsEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansInflammationMiceMice, Inbred C57BLMice, KnockoutMultiple SclerosisSingle-Cell AnalysisTh1 CellsT-Lymphocytes, RegulatoryBACH2 protein, humanBach2 protein, mouseBasic-Leucine Zipper Transcription FactorsChromatin

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.