Effect of caspase inhibitors on hemodynamics and inflammatory factors in ARDS model rats.

Aiming Liu, Fei Tian, Yaqing Zhou, Zunguo Pu

Abstract read

In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aiming Liu *Department of Critical Care Medicine, Affiliated Haian Hospital of Nantong University, No. 17 Zhongba Middle Road, Haian, Nantong, 226600, Jiangsu, China.

Fei Tian *Department of Medical Imaging, Haian Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nantong, Jiangsu, China.

Yaqing ZhouDepartment of Critical Care Medicine, Affiliated Haian Hospital of Nantong University, No. 17 Zhongba Middle Road, Haian, Nantong, 226600, Jiangsu, China. sysxzs@163.com.

Zunguo PuDepartment of Critical Care Medicine, Affiliated Haian Hospital of Nantong University, No. 17 Zhongba Middle Road, Haian, Nantong, 226600, Jiangsu, China.

Funding

Fund of science and Technology Bureau of Nantong City, Jiangsu Province JCZ19012Fund of science and Technology Bureau of Nantong City, Jiangsu Province JCZ2022122

6 · The paper itself

Abstract

To study the effects of caspase inhibitors on hemodynamics and inflammatory factors in acute respiratory distress syndrome (ARDS) model rats. Sixty healthy male Wistar rats were randomly divided into three groups, namely, the control group, ARDS group and ARDS + Caspase inhibitor group, with 20 rats in each group. The control group was intraperitoneally injected with 2 mL/kg saline, and the ARDS model group was established by intraperitoneally injecting 4 mg/kg Lipopolysaccharide (LPS), ARDS + Caspase inhibitor group was adminstered 20 mg/kg caspase inhibitor after intraperitoneal LPS injection. Changes in pulmonary arterial pressure (PAP) and mean arterial pressure (MAP) at 6 and 12 h before and after administration were recorded. Moreover, arterial blood gas was evaluated with a blood gas analyzer and changes in the partial pressure of O

Indexed as

Caspase InhibitorsDisease Models, AnimalHemodynamicsRats, WistarRespiratory Distress SyndromeAnimalsBlood Gas AnalysisInflammationInterleukin-6LipopolysaccharidesLungMalePulmonary ArteryRatsTumor Necrosis Factor-alphaCaspase InhibitorsInterleukin-6LipopolysaccharidesTumor Necrosis Factor-alphaAcute respiratory distress syndromeApoptosis repressor with a caspase recruitment domainHemodynamicsInflammatory factorsPulmonary hypertension

Identifiers

PMID39009819

DOI10.1038/s41598-024-67444-5

PMCPMC11250789

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.