Evidence map›Paper›PMID 39009790›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2024

Indium(III) complexes with lapachol: cytotoxic effects against human breast tumor cells and interactions with DNA.

Alexandre B de Carvalho, Ana M S Souza, Larissa Pereira Bento, Mariana de Oliveira Silva, Elaine M Souza-Fagundes, Renata Diniz, Heloisa Beraldo

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexandre B de CarvalhoDepartamento de Química, Universidade Federal de Minas Gerais, 31.270-901, Belo Horizonte, Minas Gerais, Brazil.
Ana M S SouzaDepartamento de Química, Universidade Federal de Minas Gerais, 31.270-901, Belo Horizonte, Minas Gerais, Brazil.
Larissa Pereira BentoDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31.270-901, Belo Horizonte, Minas Gerais, Brazil.
Mariana de Oliveira SilvaDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31.270-901, Belo Horizonte, Minas Gerais, Brazil.
Elaine M Souza-FagundesDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31.270-901, Belo Horizonte, Minas Gerais, Brazil.
Renata DinizDepartamento de Química, Universidade Federal de Minas Gerais, 31.270-901, Belo Horizonte, Minas Gerais, Brazil.
Heloisa BeraldoDepartamento de Química, Universidade Federal de Minas Gerais, 31.270-901, Belo Horizonte, Minas Gerais, Brazil. hberaldo@ufmg.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq (EMSF: 406048/2018-5) HB : 421902/2016-7 3Fundação de Amparo à Pesquisa do Estado de Minas Gerais EMSF: APQ-00428-21 HB APQ 01588-21
6 · The paper itself

Abstract

Lapachol (2-hydroxy-3-(3-methylbut-2-en-1-yl)naphthalene-1,4-dione) is a 1,4-naphthoquinone-derived natural product that presents numerous bioactivities and was shown to have cytotoxic effects against several human tumor cells. Indium(III) complexes with a variety of ligands also exhibit antineoplastic activity. Indium(III) complexes [In(lap)Cl

Indexed as

Antineoplastic AgentsBreast NeoplasmsDNAIndiumNaphthoquinonesCell Line, TumorCoordination ComplexesCrystallography, X-RayDrug Screening Assays, AntitumorFemaleHumansMCF-7 CellsModels, MolecularMolecular StructureAntineoplastic AgentsCoordination ComplexesDNAIndiumlapacholNaphthoquinonesBreast tumor cellsCytotoxic activityIndium(III) complexesLapachol

Identifiers

PMID39009790

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.