Evidence map›Paper›PMID 39009769›Full record

ReviewAnalytical and bioanalytical chemistry2024

Tailoring metal oxide nanozymes for biomedical applications: trends, limitations, and perceptions.

Parikshana Mathur, Mamta Kumawat, Rashi Nagar, Ragini Singh, Hemant Kumar Daima

Abstract readReview
PubMed Publisher
In one paragraph

Review in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Parikshana MathurDepartment of Biotechnology, School of Life Sciences, Central University of Rajasthan, NH-8, Bandarsindari, Kishangarh 305817, Ajmer, Rajasthan, India.
Mamta KumawatDepartment of Biotechnology, JECRC University, Sitapura Extension, Jaipur, 303905, Rajasthan, India.
Rashi NagarDepartment of Biotechnology, School of Life Sciences, Central University of Rajasthan, NH-8, Bandarsindari, Kishangarh 305817, Ajmer, Rajasthan, India.
Ragini SinghDepartment of Biotechnology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, 522302, Andhra Pradesh, India. raginisingh@kluniversity.in.
Hemant Kumar DaimaNanomedicine and Nanotoxicity Research Laboratory, Department of Biochemistry, School of Life Sciences, Central University of Rajasthan, NH-8, Bandarsindari, Kishangarh 305817, Ajmer, Rajasthan, India. hemant.daima@curaj.ac.in.ORCID http://orcid.org/0000-0002-9109-430X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanomaterials with enzyme-like properties are known as 'nanozymes'. Nanozymes are preferred over natural enzymes due to their nanoscale characteristics and ease of tailoring of their physicochemical properties such as size, structure, composition, surface chemistry, crystal planes, oxygen vacancy, and surface valence state. Interestingly, nanozymes can be precisely controlled to improve their catalytic ability, stability, and specificity which is unattainable by natural enzymes. Therefore, tailor-made nanozymes are being favored over natural enzymes for a range of potential applications and better prospects. In this context, metal oxide nanoparticles with nanozyme-mimicking characteristics are exclusively being used in biomedical sectors and opening new avenues for future nanomedicine. Realising the importance of this emerging area, here, we discuss the mechanistic actions of metal oxide nanozymes along with their key characteristics which affect their enzymatic actions. Further, in this critical review, the recent progress towards the development of point-of-care (POC) diagnostic devices, cancer therapy, drug delivery, advanced antimicrobials/antibiofilm, dental caries, neurodegenerative diseases, and wound healing potential of metal oxide nanozymes is deliberated. The advantages of employing metal oxide nanozymes, their potential limitations in terms of nanotoxicity, and possible prospects for biomedical applications are also discussed with future recommendations.

Indexed as

OxidesAnimalsDrug Delivery SystemsHumansMetal NanoparticlesMetalsNanomedicineNanostructuresPoint-of-Care SystemsMetalsOxidesAntibiofilmAntimicrobialsCatalytic propertiesDiagnosticsNanomedicineNanotoxicity

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.