ArticleNature communications2024
Beta activity in human anterior cingulate cortex mediates reward biases.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Resting-state EEG activity in depression: a systematic review and meta-analysis.NeuroImage. Clinical · 2026Pooled it
- Closed-loop stimulation modulates attention shifting in children.Nature neuroscience · 2026Article
- Hippocampal-cingulate dynamics in the human brain link reinforcement-learning and memory.bioRxiv : the preprint server for biology · 2026Article
- Article
- The cortical morphology of cingulate cortex and microarchitecture of cingulum bundle correlate with cancer pain and anxiety in lung cancer patients.Brain imaging and behavior · 2026Article
- Brain rhythms of depression: A predictive processing perspective.Trends in neurosciences · 2026Review
- Probing biomarkers and clinical utility of reward learning across species using the Probabilistic Reward Task: 20 years of findings.Nature. Mental health · 2026Article
- Distinct goal location beta frequency dynamics in hippocampus and prefrontal cortex across learning.bioRxiv : the preprint server for biology · 2026Article
- The diagnostic validity of central symptoms for major depressive disorder in adults with attention-deficit/hyperactivity disorder: a network analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Differential protein network and biological functions atlas from multi-tissue proteomics in patients with depression.Molecular psychiatry · 2026Article
- Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression.Archiv der Pharmazie · 2026Review
- Decisional reference point pathology: A cognitive mechanism for and a correlate of major depressive disorder in humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- ENX-104: a selective and potent DNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Common Electrophysiology Biomarkers Collected at Home Robustly Track Depression Recovery With Deep Brain Stimulation.medRxiv : the preprint server for health sciences · 2026Article
- Neural mechanisms of uncertain decision-making in anxious adolescents: an EEG study based on the balloon analogue risk task.Frontiers in psychiatry · 2026Article
- Abnormal Activation and Connection in Middle Frontal Gyrus: A Potential Imaging Feature for Facial Synkinesis Comorbid Depression.Depression and anxiety · 2026Article
- Dopamine and serotonin transients predict depressive symptom relief following deep brain stimulation of human subcallosal cingulate cortex.bioRxiv : the preprint server for biology · 2025Article
- Reward circuit local field potential modulations precede risk taking.Brain : a journal of neurology · 2025Article
- Beta and High Gamma Oscillations in the Cortico-striatal Network Reflect Reward Certainty on a Probabilistic Reversal Learning Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Brain Cortical Area Characterization and Machine Learning-Based Measure of Rasmussen's S-R-K Model.Brain sciences · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
21 authors.
Funding
Abstract
The rewards that we get from our choices and actions can have a major influence on our future behavior. Understanding how reward biasing of behavior is implemented in the brain is important for many reasons, including the fact that diminution in reward biasing is a hallmark of clinical depression. We hypothesized that reward biasing is mediated by the anterior cingulate cortex (ACC), a cortical hub region associated with the integration of reward and executive control and with the etiology of depression. To test this hypothesis, we recorded neural activity during a biased judgment task in patients undergoing intracranial monitoring for either epilepsy or major depressive disorder. We found that beta (12-30 Hz) oscillations in the ACC predicted both associated reward and the size of the choice bias, and also tracked reward receipt, thereby predicting bias on future trials. We found reduced magnitude of bias in depressed patients, in whom the beta-specific effects were correspondingly reduced. Our findings suggest that ACC beta oscillations may orchestrate the learning of reward information to guide adaptive choice, and, more broadly, suggest a potential biomarker for anhedonia and point to future development of interventions to enhance reward impact for therapeutic benefit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.