Evidence map›Paper›PMID 39009450›Full record

ArticleTobacco control2025

Universal smoking machine adaptor for tobacco product testing.

Ahmad El-Hellani, Clifford H Watson, Michelle Huang, Clark W Wilson, Clint C Fleshman, Ryan Petitti, Mary Pancake, Chad Bennett, Brittney L Keller-Hamilton, Jeremy Jones and 9 more

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Tobacco control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ahmad El-HellaniDivision of Environmental Health Sciences, The Ohio State University College of Public Health, Columbus, Ohio, USA.ORCID 0000-0002-1047-0597
Clifford H WatsonTobacco and Volatiles Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Michelle HuangTobacco and Volatiles Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Clark W WilsonCenter for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.
Clint C FleshmanCenter for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.
Ryan PetittiCenter for Design and Manufacturing Excellence, The Ohio State University, Columbus, Ohio, USA.
Mary PancakeCenter for Design and Manufacturing Excellence, The Ohio State University, Columbus, Ohio, USA.
Chad BennettMedicinal Chemistry Shared Resource, Drug Development Institute, The Ohio State University, Columbus, Ohio, USA.
Brittney L Keller-HamiltonCenter for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.
Jeremy JonesProduced Better, Alpharetta, Georgia, USA.
Hang TranTobacco and Volatiles Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0002-6036-6229
Roberto Bravo CardenasTobacco and Volatiles Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Darren MaysCenter for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.ORCID 0000-0002-6605-0743
Wei YeCenter for Tobacco Products, US Food and Drug Administration, Silver Spring, Maryland, USA.
Robert P BorthwickCenter for Tobacco Products, US Food and Drug Administration, Silver Spring, Maryland, USA.
Jason SchaffCenter for Tobacco Products, US Food and Drug Administration, Silver Spring, Maryland, USA.
Raymond L WilliamsonCenter for Tobacco Products, US Food and Drug Administration, Silver Spring, Maryland, USA.
Theodore L WagenerCenter for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.ORCID 0000-0002-9072-228X
Marielle C BrinkmanCenter for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA brinkman.224@osu.edu.ORCID 0000-0002-4315-649X

Funding

Smoking Machine Adaptor Design Project for ENDS, Cigars, and Heated Tobacco Products (UC2)UC2FD007229 · FDA · OHIO STATE UNIVERSITY · PI BRINKMAN, MARIELLE CAVANAUGH, WAGENER, THEODORE LEE · 2021 to 2025
$5.1M
FDA HHS UC2 FD007229
6 · The paper itself

Abstract

significanceHistorically, tobacco product emissions testing using smoking machines has largely focused on combustible products, such as cigarettes and cigars. However, the popularity of newer products, such as electronic cigarettes (e-cigarettes), has complicated emissions testing because the products' mouth-end geometries do not readily seal with existing smoking and vaping machines. The demand for emissions data on popularly used products has led to inefficient and non-standardised solutions, such as laboratories making their geometry-specific custom adaptors and/or employing flexible tubing, for each unique mouth-end geometry tested. A user-friendly, validated, universal smoking machine adaptor (USMA) is needed for testing the variety of tobacco products reflecting consumer use, including e-cigarettes, heated tobacco products, cigarettes, plastic-tipped cigarillos and cigars.

methodsA prototype USMA that is compatible with existing smoking/vaping machines was designed and fabricated. The quality of the seal between the USMA and different tobacco products, including e-cigarettes, cigars and cigarillos, was evaluated by examining the leak rate.

resultsUnlike commercial, product-specific adaptors, the USMA seals well with a wide range of tobacco product mouth-end geometries and masses. This includes e-cigarettes with non-cylindrical mouth ends and cigarillos with cuboid-like plastic tips. USMA leak rates were lower than or equivalent to commercial, product-specific adaptors.

conclusionThis report provides initial evidence that the USMA seals reliably with a variety of tobacco product mouth-end geometries and can be used with existing linear smoking/vaping machines to potentially improve the precision, repeatability and reproducibility of machine smoke yield data. Accurate and reproducible emissions testing is critical for regulating tobacco products.

Indexed as

Electronic Nicotine Delivery SystemsEnvironmental MonitoringSmokeTobacco ProductsEquipment DesignHumansMechanical TestsReproducibility of ResultsSmokeElectronic nicotine delivery devicesNon-cigarette tobacco productsPublic policyTobacco industry

Identifiers

PMID39009450
PMCPMC13293474

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.