Evidence map›Paper›PMID 39009449›Full record

ArticleTobacco control2025

Benchmarking a universal smoking machine adaptor for tobacco product testing.

Ahmad El-Hellani, Clifford H Watson, Michelle Huang, Clark W Wilson, Clint C Fleshman, Hang Tran, Dana Chafin, Megan McGuigan, Roberto Bravo Cardenas, Ryan Petitti and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tobacco control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ahmad El-HellaniDivision of Environmental Health Sciences, The Ohio State University College of Public Health, Columbus, Ohio, USA.ORCID 0000-0002-1047-0597
Clifford H WatsonTobacco Products Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Michelle HuangTobacco Products Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Clark W WilsonCenter for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.
Clint C FleshmanCenter for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.
Hang TranTobacco Products Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0002-6036-6229
Dana ChafinTobacco Products Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Megan McGuiganTobacco Products Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Roberto Bravo CardenasTobacco Products Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Ryan PetittiCenter for Design and Manufacturing Excellence, The Ohio State University, Columbus, Ohio, USA.
Mary PancakeCenter for Design and Manufacturing Excellence, The Ohio State University, Columbus, Ohio, USA.
Chad BennettMedicinal Chemistry Shared Resource, Drug Development Institute, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.
Darren MaysCenter for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.ORCID 0000-0002-6605-0743
Brittney L Keller-HamiltonCenter for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.
Jeremy JonesProduced Better, Columbus, Ohio, USA.
Wei YeCenter for Tobacco Products, US Food and Drug Administration, Silver Spring, Maryland, USA.
Jason SchaffCenter for Tobacco Products, US Food and Drug Administration, Silver Spring, Maryland, USA.
Robert P BorthwickCenter for Tobacco Products, US Food and Drug Administration, Silver Spring, Maryland, USA.
Raymond L WilliamsonCenter for Tobacco Products, US Food and Drug Administration, Silver Spring, Maryland, USA.
Theodore L WagenerCenter for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.ORCID 0000-0002-9072-228X
Marielle C BrinkmanCenter for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA brinkman.224@osu.edu.ORCID 0000-0002-4315-649X

Funding

FDA HHS UC2 FD007229
6 · The paper itself

Abstract

significanceCharacterisation of tobacco product emissions is an important step in assessing their impact on public health. Accurate and repeatable emissions data require that a leak-tight seal be made between the smoking or vaping machine and the mouth-end of the tobacco product being tested. This requirement is challenging because of the variety of tobacco product mouth-end geometries being puffed on by consumers today. We developed and tested a prototype universal smoking machine adaptor (USMA) that interfaces with existing machines and reliably seals with a variety of tobacco product masses and geometries.

methodsEmissions were machine-generated using the USMA and other available adaptors for a variety of electronic cigarettes (n=7 brands), cigars (n=4), cigarillos (n=2), a heated tobacco product, and a reference cigarette (1R6F), and mainstream total particulate matter (TPM) and nicotine were quantified. Data variability (precision, n≥10 replicates/brand) for all products and error (accuracy) from certified values (1R6F) were compared across adaptors.

resultsTPM and nicotine emissions generated using the USMA were accurate, precise and agreed with certified values for the 1R6F reference cigarette. Replicate data indicate that USMA repeatability across all tobacco products tested generally meets or exceeds that from the comparison adaptors and extant data.

conclusionThe USMA seals well with a variety of combustible tobacco products, e-cigarettes with differing geometries and plastic-tipped cigarillos. Variability for all measures was similar or smaller for the USMA compared with other adaptors.

Indexed as

BenchmarkingTobacco ProductsElectronic Nicotine Delivery SystemsHumansNicotineParticulate MatterVapingNicotineParticulate MatterCarcinogensElectronic nicotine delivery devicesNon-cigarette tobacco productsSmoking topographySurveillance and monitoring

Identifiers

PMID39009449
PMCPMC13251369

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.