Evidence map›Paper›PMID 39009239›Full record

ArticleAmerican journal of ophthalmology2024

Glaucomatous Focal Perfusion Loss in the Macula Measured by Optical Coherence Tomographic Angiography.

Aiyin Chen, Ping Wei, Jie Wang, Liang Liu, Acner Camino, Yukun Guo, Ou Tan, Yali Jia, David Huang

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Optical coherence tomography angiography of the macular retina and choroid in glaucoma: a narrative review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aiyin ChenFrom the Casey Eye Institute and Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.
Ping WeiFrom the Casey Eye Institute and Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.
Jie WangFrom the Casey Eye Institute and Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.
Liang LiuFrom the Casey Eye Institute and Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.
Acner CaminoFrom the Casey Eye Institute and Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.
Yukun GuoFrom the Casey Eye Institute and Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.
Ou TanFrom the Casey Eye Institute and Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.
Yali JiaFrom the Casey Eye Institute and Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.
David HuangFrom the Casey Eye Institute and Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.. Electronic address: davidhuang@alum.mit.edu.

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Kate E Keller · 1995 to 2026
$19.4M
STUDIES IN GLAUCOMATOUS OPTIC NERVE DAMAGER01EY010145 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI MORRISON, JOHN C · 1993 to 2023
$8.9M
Functional and Structural Optical Coherence Tomography for GlaucomaR01EY023285 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI David Huang · 2013 to 2026
$8.8M
OCT Angiography for Neovascular Age-related Macular DegenerationR01EY024544 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Steven T Bailey, Yali Jia · 2014 to 2026
$6.2M
OCTA Precursors of Vision-Threatening Complications of Diabetic RetinopathyR01EY035410 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Thomas Hwang, Yali Jia · 2023 to 2026
$2.5M
Mentored Vision Clinician-Scientist Program at OHSUK12EY027720 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI David Huang · 2018 to 2026
$2.2M
Visible-light OCT angiography, velocimetry, and oximetry for characterizing retinal vascular alterations in glaucomaR01EY031394 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI JIA, YALI, MORRISON, JOHN C · 2020 to 2022
$1.6M
NEI NIH HHS K12 EY027720NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY010145NEI NIH HHS R01 EY023285NEI NIH HHS R01 EY024544NEI NIH HHS R01 EY031394NEI NIH HHS R01 EY035410
6 · The paper itself

Abstract

purposeTo measure low perfusion area (LPA) and focal perfusion loss (FPL) in the macula using optical coherence tomography (OCT) angiography (OCTA) for glaucoma.

designProspective, cross-sectional "case-control" comparison study.

methodsA total of 60 patients with primary open-angle glaucoma (POAG) and 37 healthy participants were analyzed. AngioVue 6 × 6-mm high-definition (400 × 400 transverse pixels) macular OCTA scans were performed on one eye of each participant. Flow signal was calculated using the split-spectrum amplitude-decorrelation angiography algorithm. En face ganglion cell layer plexus (GCLP) and superficial vascular complex (SVC) images were generated. Using custom software, vessel density (VD) maps were obtained by computing the fraction of area occupied by flow pixels after low-pass filtering by local averaging 41 × 41 pixels. LPA was defined by local VD below 0.5 percentile over a contiguous area above 98.5 percentile of the healthy reference population. The FPL was the percentage VD loss (relative to normal mean) integrated over the LPA.

resultsAmong patients with POAG, 30 had perimetric and 30 had preperimetric glaucoma. The LPA

conclusionAssessment of macular FPL using OCTA is useful in evaluating glaucomatous damage.

Indexed as

Fluorescein AngiographyGlaucoma, Open-AngleIntraocular PressureMacula LuteaRetinal Ganglion CellsRetinal VesselsTomography, Optical CoherenceAgedCase-Control StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedNerve FibersOptic Disk

Identifiers

PMID39009239
PMCPMC11606794

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.