Evidence map›Paper›PMID 39009104›Full record

ArticleMitochondrion2024

Longitudinal changes in mitochondrial-associated measures and insulin resistance in youth with perinatally-acquired HIV in the U.S.

Greg S Gojanovich, Wendy Yu, Zhongli J Zhang, Denise L Jacobson, Tzy-Jyun Yao, Jennifer Jao, Daniel E Libutti, Mitchell E Geffner, Mariana Gerschenson, Pediatric HIV/AIDS Cohort Study

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mitochondrion, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01418014 completednot on this map

Adolescent Master Protocol

TypeobservationalSponsorHarvard School of Public Health (HSPH)Ran2007 to 2021Enrolled678ConditionsHIV/AIDS
NCT02119702 completednot on this map

Adolescent Master Protocol for Participants 18 Years of Age and Older (AMP Up)

TypeobservationalSponsorHarvard School of Public Health (HSPH)Ran2014 to 2025Enrolled818ConditionsHIV/AIDS
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Greg S GojanovichDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Wendy YuCenter for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Zhongli J ZhangCenter for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Denise L JacobsonCenter for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Tzy-Jyun YaoCenter for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Jennifer JaoDepartment of Pediatrics, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60642, USA.
Daniel E LibuttiDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Mitchell E GeffnerSaban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Mariana GerschensonDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Pediatric HIV/AIDS Cohort Study

Funding

PHACS - Data and Operations CenterU01HD052102 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLIAMS, PAIGE L · 2005 to 2019
$242.7M
The Adolescent Master Protocol (AMP) Up Series ProjectP01HD103133 · NICHD · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI CHADWICK, ELLEN GOULD, HERNANDEZ-DIAZ, SONIA · 2020 to 2024
$88.3M
UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3M
The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI JoAnn Umilani Tsark · 2017 to 2026
$59.5M
TRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Kathryn Jaques Schunke · 2017 to 2026
$21.5M
RESEARCH DESIGN AND BIOSTATISTICS COREU54MD007584 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI HEDGES, JERRIS ROBERT, MOKUAU, NOREEN · 2012 to 2018
$21.1M
Pediatric HIV/AIDS Cohort Study (PHACS): Understanding Maternal HIV Disease through Pregnancy and the Postpartum Period and its Role in Child Health OutcomesU01HD052104 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI VAN DYKE, RUSSELL B. · 2005 to 2019
$15.7M
Training in Cardiovascular Research at the University of HawaiiT32HL115505 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI Michelle D Tallquist · 2012 to 2026
$3.8M
Mitochondrial Determinants of Metabolic Disease in HIV-Infected ChildrenR01NR012885 · NINR · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GERSCHENSON, MARIANA, MILLER, TRACIE L · 2010 to 2014
$2.5M
NHLBI NIH HHS T32 HL115505NICHD NIH HHS P01 HD103133NICHD NIH HHS U01 HD052102NICHD NIH HHS U01 HD052104NIGMS NIH HHS P20 GM103466NIGMS NIH HHS P20 GM113134NIMHD NIH HHS U54 MD007584NIMHD NIH HHS U54 MD007601NINR NIH HHS R01 NR012885
6 · The paper itself

Abstract

HIV infection and its treatment are associated with mitochondrial dysfunction and metabolic derangement. However, longitudinal changes in oxidative phosphorylation activities [Complex I (C1) and Complex IV (C4)], or venous lactate/pyruvate ratios (LPR), and their relationships with insulin resistance (IR), remain unclear in youth living with perinatally-acquired HIV (YPHIV). We measured venous LPR, C1, and C4 activities in blood cells and homeostatic model assessment for IR (HOMA-IR) over two years. Limited longitudinal differences in mitochondrial-related measures and IR were observed in YPHIV vs youth perinatally HIV-exposed but uninfected. There were no systematic differences in C1, C4, or HOMA-IR between the groups.

Indexed as

HIV InfectionsInsulin ResistanceAdolescentChildElectron Transport Complex IElectron Transport Complex IVFemaleHumansInfectious Disease Transmission, VerticalLactic AcidLongitudinal StudiesMaleMitochondriaOxidative PhosphorylationPyruvic AcidUnited StatesElectron Transport Complex IElectron Transport Complex IVLactic AcidPyruvic AcidInsulin resistanceLactateMitochondriaOxidative phosphorylationPerinatal HIVYouth

Identifiers

PMID39009104
PMCPMC11390301

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.