Evidence map›Paper›PMID 39008906›Full record

ReviewAnnual review of microbiology2024

Periplasmic Chaperones: Outer Membrane Biogenesis and Envelope Stress.

Ashton N Combs, Thomas J Silhavy

Abstract readReview
In one paragraph

Review in Annual review of microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A mechanism for substrate quality control in outer membrane protein assembly.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Review
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ashton N CombsDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA; email: tsilhavy@princeton.edu.
Thomas J SilhavyDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA; email: tsilhavy@princeton.edu.

Funding

Biogenesis and maintenance of the outer membrane of Gram-negative bacteriaR35GM118024 · NIGMS · PRINCETON UNIVERSITY · PI SILHAVY, THOMAS J. · 2016 to 2025
$8.1M
NIGMS NIH HHS R35 GM118024
6 · The paper itself

Abstract

Envelope biogenesis and homeostasis in gram-negative bacteria are exceptionally intricate processes that require a multitude of periplasmic chaperones to ensure cellular survival. Remarkably, these chaperones perform diverse yet specialized functions entirely in the absence of external energy such as ATP, and as such have evolved sophisticated mechanisms by which their activities are regulated. In this article, we provide an overview of the predominant periplasmic chaperones that enable efficient outer membrane biogenesis and envelope homeostasis in

Indexed as

Escherichia coliMolecular ChaperonesPeriplasmBacterial Outer MembraneBacterial Outer Membrane ProteinsCell MembraneEscherichia coli ProteinsHomeostasisStress, PhysiologicalBacterial Outer Membrane ProteinsEscherichia coli ProteinsMolecular Chaperonesenvelope stress responsesgram-negative cell envelopeouter membrane protein biogenesisperiplasmperiplasmic chaperonesperiplasmic proteases

Identifiers

PMID39008906
PMCPMC12107694

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.