Evidence map›Paper›PMID 39008785›Full record

ArticleNeurology2024

Associations of Cerebral Blood Flow Patterns With Gray and White Matter Structure in Patients With Temporal Lobe Epilepsy.

Alexander Ngo, Jessica Royer, Raul Rodriguez-Cruces, Ke Xie, Jordan DeKraker, Hans Auer, Shahin Tavakol, Jack Lam, Dewi V Schrader, Roy W R Dudley and 5 more

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In one paragraph

Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it

0cells of the map it votes in

10citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

Assessing cognitive impairment in epilepsy using Arterial spin-labeled (ASL) perfusion imaging.Brain imaging and behavior · 2026
Article
Developmental human brain connectome from fetal stage to early childhood.Developmental cognitive neuroscience · 2026
Review
Arterial spin labeling MRI with multiple post-labeling delays reveals interictal hypo- and hyper-perfusion patterns in epilepsy: A proof of concept.Journal of neuroradiology = Journal de neuroradiologie · 2026
Article
HippoMaps: multiscale cartography of human hippocampal organization.Nature methods · 2025
Article
Blood‑brain barrier dysfunction in epilepsy: Mechanisms, therapeutic strategies and future orientation (Review).International journal of molecular medicine · 2025
Review
Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan.PLoS biology · 2025
Article
ILAE neuroimaging task force highlight: The utility of multimodal neuroimaging in diagnostic and presurgical workup of drug-resistant focal epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2025
Article
Normative Cerebral Perfusion Across the Lifespan.ArXiv · 2025
Article
A review of brain research on T2DM-related cognitive dysfunction.Open medicine (Warsaw, Poland) · 2025
Review
Functional ultrasound assessment of cerebral blood flow and brain connectivity in a pilocarpine-induced acute epileptic seizures in mice.Frontiers in neurology
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Alexander NgoFrom the Department of Neurology and Neurosurgery (A.N., J.R., R.R.-C., K.X., J.D., H.A., S.T., J.L., A.B., N.B., B.F., B.C.B.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec; Department of Pediatrics (D.V.S.), University of British Columbia, Vancouver; Department of Pediatric Surgery (R.W.R.D.), Montreal Children's Hospital, McGill University, Montreal, Québec, Canada; and Center for Brain Circuit Therapeutics (S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-8999-9388

Jessica RoyerFrom the Department of Neurology and Neurosurgery (A.N., J.R., R.R.-C., K.X., J.D., H.A., S.T., J.L., A.B., N.B., B.F., B.C.B.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec; Department of Pediatrics (D.V.S.), University of British Columbia, Vancouver; Department of Pediatric Surgery (R.W.R.D.), Montreal Children's Hospital, McGill University, Montreal, Québec, Canada; and Center for Brain Circuit Therapeutics (S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Raul Rodriguez-CrucesFrom the Department of Neurology and Neurosurgery (A.N., J.R., R.R.-C., K.X., J.D., H.A., S.T., J.L., A.B., N.B., B.F., B.C.B.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec; Department of Pediatrics (D.V.S.), University of British Columbia, Vancouver; Department of Pediatric Surgery (R.W.R.D.), Montreal Children's Hospital, McGill University, Montreal, Québec, Canada; and Center for Brain Circuit Therapeutics (S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Ke XieFrom the Department of Neurology and Neurosurgery (A.N., J.R., R.R.-C., K.X., J.D., H.A., S.T., J.L., A.B., N.B., B.F., B.C.B.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec; Department of Pediatrics (D.V.S.), University of British Columbia, Vancouver; Department of Pediatric Surgery (R.W.R.D.), Montreal Children's Hospital, McGill University, Montreal, Québec, Canada; and Center for Brain Circuit Therapeutics (S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Jordan DeKrakerFrom the Department of Neurology and Neurosurgery (A.N., J.R., R.R.-C., K.X., J.D., H.A., S.T., J.L., A.B., N.B., B.F., B.C.B.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec; Department of Pediatrics (D.V.S.), University of British Columbia, Vancouver; Department of Pediatric Surgery (R.W.R.D.), Montreal Children's Hospital, McGill University, Montreal, Québec, Canada; and Center for Brain Circuit Therapeutics (S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Hans AuerFrom the Department of Neurology and Neurosurgery (A.N., J.R., R.R.-C., K.X., J.D., H.A., S.T., J.L., A.B., N.B., B.F., B.C.B.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec; Department of Pediatrics (D.V.S.), University of British Columbia, Vancouver; Department of Pediatric Surgery (R.W.R.D.), Montreal Children's Hospital, McGill University, Montreal, Québec, Canada; and Center for Brain Circuit Therapeutics (S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0003-2127-4636

Shahin TavakolFrom the Department of Neurology and Neurosurgery (A.N., J.R., R.R.-C., K.X., J.D., H.A., S.T., J.L., A.B., N.B., B.F., B.C.B.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec; Department of Pediatrics (D.V.S.), University of British Columbia, Vancouver; Department of Pediatric Surgery (R.W.R.D.), Montreal Children's Hospital, McGill University, Montreal, Québec, Canada; and Center for Brain Circuit Therapeutics (S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Jack LamFrom the Department of Neurology and Neurosurgery (A.N., J.R., R.R.-C., K.X., J.D., H.A., S.T., J.L., A.B., N.B., B.F., B.C.B.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec; Department of Pediatrics (D.V.S.), University of British Columbia, Vancouver; Department of Pediatric Surgery (R.W.R.D.), Montreal Children's Hospital, McGill University, Montreal, Québec, Canada; and Center for Brain Circuit Therapeutics (S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Dewi V SchraderFrom the Department of Neurology and Neurosurgery (A.N., J.R., R.R.-C., K.X., J.D., H.A., S.T., J.L., A.B., N.B., B.F., B.C.B.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec; Department of Pediatrics (D.V.S.), University of British Columbia, Vancouver; Department of Pediatric Surgery (R.W.R.D.), Montreal Children's Hospital, McGill University, Montreal, Québec, Canada; and Center for Brain Circuit Therapeutics (S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Roy W R DudleyFrom the Department of Neurology and Neurosurgery (A.N., J.R., R.R.-C., K.X., J.D., H.A., S.T., J.L., A.B., N.B., B.F., B.C.B.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec; Department of Pediatrics (D.V.S.), University of British Columbia, Vancouver; Department of Pediatric Surgery (R.W.R.D.), Montreal Children's Hospital, McGill University, Montreal, Québec, Canada; and Center for Brain Circuit Therapeutics (S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0003-4437-0823

Andrea BernasconiFrom the Department of Neurology and Neurosurgery (A.N., J.R., R.R.-C., K.X., J.D., H.A., S.T., J.L., A.B., N.B., B.F., B.C.B.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec; Department of Pediatrics (D.V.S.), University of British Columbia, Vancouver; Department of Pediatric Surgery (R.W.R.D.), Montreal Children's Hospital, McGill University, Montreal, Québec, Canada; and Center for Brain Circuit Therapeutics (S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0001-9358-5703

Neda BernasconiFrom the Department of Neurology and Neurosurgery (A.N., J.R., R.R.-C., K.X., J.D., H.A., S.T., J.L., A.B., N.B., B.F., B.C.B.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec; Department of Pediatrics (D.V.S.), University of British Columbia, Vancouver; Department of Pediatric Surgery (R.W.R.D.), Montreal Children's Hospital, McGill University, Montreal, Québec, Canada; and Center for Brain Circuit Therapeutics (S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Birgit FrauscherFrom the Department of Neurology and Neurosurgery (A.N., J.R., R.R.-C., K.X., J.D., H.A., S.T., J.L., A.B., N.B., B.F., B.C.B.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec; Department of Pediatrics (D.V.S.), University of British Columbia, Vancouver; Department of Pediatric Surgery (R.W.R.D.), Montreal Children's Hospital, McGill University, Montreal, Québec, Canada; and Center for Brain Circuit Therapeutics (S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0001-6064-1529

Sara LariviereFrom the Department of Neurology and Neurosurgery (A.N., J.R., R.R.-C., K.X., J.D., H.A., S.T., J.L., A.B., N.B., B.F., B.C.B.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec; Department of Pediatrics (D.V.S.), University of British Columbia, Vancouver; Department of Pediatric Surgery (R.W.R.D.), Montreal Children's Hospital, McGill University, Montreal, Québec, Canada; and Center for Brain Circuit Therapeutics (S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Boris C BernhardtFrom the Department of Neurology and Neurosurgery (A.N., J.R., R.R.-C., K.X., J.D., H.A., S.T., J.L., A.B., N.B., B.F., B.C.B.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec; Department of Pediatrics (D.V.S.), University of British Columbia, Vancouver; Department of Pediatric Surgery (R.W.R.D.), Montreal Children's Hospital, McGill University, Montreal, Québec, Canada; and Center for Brain Circuit Therapeutics (S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0001-9256-6041

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesNeuroimaging studies in patients with temporal lobe epilepsy (TLE) show widespread brain network alterations beyond the mesiotemporal lobe. Despite the critical role of the cerebrovascular system in maintaining whole-brain structure and function, changes in cerebral blood flow (CBF) remain incompletely understood in the disease. Here, we studied whole-brain perfusion and vascular network alterations in TLE and assessed its associations with gray and white matter compromises and various clinical variables.

methodsWe included individuals with and without pharmaco-resistant TLE who underwent multimodal 3T MRI, including arterial spin labelling, structural, and diffusion-weighted imaging. Using surface-based MRI mapping, we generated individualized cortico-subcortical profiles of perfusion, morphology, and microstructure. Linear models compared regional CBF in patients with controls and related alterations to morphological and microstructural metrics. We further probed interregional vascular networks in TLE, using graph theoretical CBF covariance analysis. The effects of disease duration were explored to better understand the progressive changes in perfusion. We assessed the utility of perfusion in separating patients with TLE from controls using supervised machine learning.

resultsCompared with control participants (n = 38; mean ± SD age 34.8 ± 9.3 years; 20 females), patients with TLE (n = 24; mean ± SD age 35.8 ± 10.6 years; 12 females) showed widespread CBF reductions predominantly in fronto-temporal regions (Cohen DISCUSSION: Our multimodal findings provide insights into vascular contributions to TLE pathophysiology affecting and extending beyond mesiotemporal structures and highlight their clinical potential in epilepsy diagnosis. As our work was cross-sectional and based on a single site, it motivates future longitudinal studies to confirm progressive effects, ideally in a multicentric setting.

Indexed as

Cerebrovascular CirculationEpilepsy, Temporal LobeGray MatterWhite MatterAdultDiffusion Magnetic Resonance ImagingDrug Resistant EpilepsyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedSupervised Machine LearningYoung Adult

Identifiers

PMID39008785

DOI10.1212/WNL.0000000000209528

PMCPMC11314957

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