ArticleJournal of clinical gastroenterology
The Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation.
Article in Journal of clinical gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Palliative Care Co-management at a Liver Transplant Center: A Mixed Methods Study.Digestive diseases and sciences · 2026Article
- Characterizing Abdominal Pain and Irritable Bowel Syndrome Among Individuals With Cirrhosis: Results of a Nationwide Survey.Gastro hep advances · 2026Review
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Authors and funding
9 authors.
Funding
Abstract
GOALS AND
backgroundPatients with cirrhosis undergoing liver transplant evaluation have high rates of pain and mental health comorbidities; both may significantly impair health-related quality of life (HRQL). We investigated the association between pain, anxiety/depression, and HRQL in this population. STUDY: In 62 patients with cirrhosis undergoing liver transplant evaluation, we performed 4 validated assessments to characterize: pain (Brief Pain Inventory-Short Form, BPI-SF), anxiety (Generalized Anxiety Disorder-7), depression (Patient Health Questionnaire-8), and liver-specific HRQL (Chronic Liver Disease Questionnaire). The presence of pain was determined using the BPI-SF screening question. Linear regression was used to identify demographic or clinical factors predictive of pain severity (PS) and interference (PI) and to evaluate the association between pain, anxiety/depression, and HRQL.
resultsSeventy-one percent of patients reported pain, 26% had clinical depression, and 24% had moderate-severe anxiety. Neither liver disease severity, nor its complications were associated with pain (PS or PI), but anxiety and depression were predictors of pain on bivariate analysis. Only depression remained a significant predictor of PS ( b =0.28, P<0.05 ) and PI ( b =0.30, P <0.05) in multivariable models. HRQL was inversely associated with PS, PI, depression, and anxiety, but only anxiety ( b =-0.14, P =0.003) remained associated with HRQL in the adjusted model.
conclusionsPain is present in over 70% of patients with cirrhosis undergoing liver transplant evaluation. Anxiety and depression were highly correlated with pain and appeared to be key drivers in predicting poor HRQL. Evaluating and managing mental health comorbidities should be explored as a strategy to improve HRQL in patients with cirrhosis and pain.
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