Evidence map›Paper›PMID 39008559›Full record

ArticleCirculation2024

Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, and Cardiovascular Disease Risk in US Hispanics and Latinos: Results From HCHS/SOL.

Yi Wang, Guo-Chong Chen, Zheng Wang, Kai Luo, Yanbo Zhang, Yang Li, Amanda C McClain, Marta M Jankowska, Krista M Perreira, Josiemer Mattei and 15 more

Abstract read
In one paragraph

Article in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

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20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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  14. Gut-heart axis: cardiac remodeling and heart failure in the context of inflammatory bowel disease and dysbiosis.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Yi WangDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.W., G.-C.C., Z.W., K.L., Y.Z., Y.L., C.R.I., R.D.B., R.C.K., Q.Q., B.A.P.).ORCID 0000-0001-6965-9696
Guo-Chong ChenDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.W., G.-C.C., Z.W., K.L., Y.Z., Y.L., C.R.I., R.D.B., R.C.K., Q.Q., B.A.P.).
Zheng WangDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.W., G.-C.C., Z.W., K.L., Y.Z., Y.L., C.R.I., R.D.B., R.C.K., Q.Q., B.A.P.).ORCID 0000-0003-2052-5552
Kai LuoDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.W., G.-C.C., Z.W., K.L., Y.Z., Y.L., C.R.I., R.D.B., R.C.K., Q.Q., B.A.P.).ORCID 0000-0001-6453-3699
Yanbo ZhangDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.W., G.-C.C., Z.W., K.L., Y.Z., Y.L., C.R.I., R.D.B., R.C.K., Q.Q., B.A.P.).ORCID 0000-0003-1054-9657
Yang LiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.W., G.-C.C., Z.W., K.L., Y.Z., Y.L., C.R.I., R.D.B., R.C.K., Q.Q., B.A.P.).
Amanda C McClainSchool of Exercise and Nutritional Sciences, San Diego State University, CA (A.C.M.).ORCID 0000-0002-4222-7460
Marta M JankowskaPopulation Sciences, Beckman Research Institute, City of Hope, Duarte, CA (M.M.J.).ORCID 0000-0002-8688-1181
Krista M PerreiraDepartment of Social Medicine, University of North Carolina at Chapel Hill (K.M.P.).ORCID 0000-0003-2906-0261
Josiemer MatteiDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.M.).ORCID 0000-0001-5424-8245
Carmen R IsasiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.W., G.-C.C., Z.W., K.L., Y.Z., Y.L., C.R.I., R.D.B., R.C.K., Q.Q., B.A.P.).ORCID 0000-0003-2700-9593
Maria M LlabreDepartment of Psychology, University of Miami, FL (M.M.L.).
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (B.T.).ORCID 0000-0001-6968-6985
Martha L DaviglusInstitute for Minority Health Research, University of Illinois Chicago (M.L.D.).ORCID 0000-0002-6791-8727
Linda Van HornDepartment of Preventive Medicine, Northwestern University, Chicago, IL (L.V.H.).ORCID 0000-0002-1362-5806
David Goldsztajn FareloBoston Fusion Corp, Lexington, MA (D.G.F.).ORCID 0000-0003-4664-5798
Luis E MaldonadoDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles (L.E.M.).ORCID 0000-0003-4550-9241
Steven R LevineSUNY Downstate Health Sciences University, Brooklyn, NY (S.R.L.).ORCID 0000-0002-7451-7534
Bing YuDepartment of Epidemiology (B.Y.), School of Public Health, University of Texas Health Science Center at Houston, Houston.ORCID 0000-0003-4818-1077
Eric BoerwinkleDepartment of Epidemiology, Human Genetics, and Environmental Sciences (E.B.), School of Public Health, University of Texas Health Science Center at Houston, Houston.ORCID 0000-0001-8813-0544
Rob KnightDepartments of Pediatrics, Computer Science and Engineering, Bioengineering, and Center for Microbiome Innovation, University of California San Diego, La Jolla (R.K.).ORCID 0000-0002-0975-9019
Robert D BurkDepartments of Pediatrics, Microbiology & Immunology, and Obstetrics, Gynecology & Women's Health, Albert Einstein College of Medicine, Bronx, NY(R.D.B.).ORCID 0000-0002-8376-8458
Robert C KaplanDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (R.C.K.).ORCID 0000-0003-1571-4615
Qibin QiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.W., G.-C.C., Z.W., K.L., Y.Z., Y.L., C.R.I., R.D.B., R.C.K., Q.Q., B.A.P.).ORCID 0000-0002-2687-1758
Brandilyn A PetersDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.W., G.-C.C., Z.W., K.L., Y.Z., Y.L., C.R.I., R.D.B., R.C.K., Q.Q., B.A.P.).ORCID 0000-0002-1534-2578

Funding

Sex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosisU01HL146204 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI David B. Hanna, Anjali Sharma · 2019 to 2026
$33.2M
MWCCS: Brooklyn Clinical Research SiteU01HL146202 · NHLBI · SUNY DOWNSTATE MEDICAL CENTER · PI TRACEY ELIZABETH WILSON, Jessica Eve Yager · 2019 to 2026
$23.6M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
Epidemiology of the gut microbiome, prediabetes and diabetes in LatinosR01MD011389 · NIMHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BURK, ROBERT D, KAPLAN, ROBERT C · 2016 to 2020
$4.3M
Immunophenotyping for precision medicine for cardiovascular disease in people living with HIVR01HL148094 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KAPLAN, ROBERT C, LEY, KLAUS F. · 2019 to 2022
$3.3M
Integrated analysis of CVD risk in HIV: gut microbiota, immune function and metabolitesR01HL140976 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KAPLAN, ROBERT C, KNIGHT, ROB · 2018 to 2021
$3.3M
Metabolic Signatures Underlying Cardiac Function for Heart Failure in Multi-Ethnic PopulationsR01HL141824 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YU, BING · 2018 to 2021
$3.1M
Thalassemia Clinical Research Network, CanadaU01HL065233 · NHLBI · UNIVERSITY HEALTH NETWORK · PI OLIVIERI, NANCY F · 2000 to 2009
$2.6M
Human Gut Microbiome and Incident Diabetes Risk in U.S. PopulationsR01DK126698 · NIDDK · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI QI, QIBIN, SUN, QI · 2021 to 2024
$2.5M
Metabolomics signatures underlying diet, lifestyle and gut microbiota for diabetesR01DK119268 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI QI, QIBIN · 2019 to 2022
$2.4M
GENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1R01HL065234 · NHLBI · VANDERBILT UNIVERSITY · PI MOORE, JASON H. · 2000 to 2004
$1.7M
NHGRI NIH HHS HHSN268201300003CNHLBI NIH HHS HHSN268201300003INHLBI NIH HHS K01 HL150406NHLBI NIH HHS K01 HL160146NHLBI NIH HHS K01 HL169019NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R01 HL140976NHLBI NIH HHS R01 HL141824NHLBI NIH HHS R01 HL148094NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146204NIDDK NIH HHS P30 DK111022NIDDK NIH HHS R01 DK119268NIDDK NIH HHS R01 DK126698NIEHS NIH HHS P30 ES027792NIMHD NIH HHS R01 MD011389
6 · The paper itself

Abstract

backgroundDietary acculturation, or adoption of dominant culture diet by migrant groups, influences human health. We aimed to examine dietary acculturation and its relationships with cardiovascular disease (CVD), gut microbiota, and blood metabolites among US Hispanic and Latino adults.

methodsIn the HCHS/SOL (Hispanic Community Health Study/Study of Latinos), US exposure was defined by years in the United States (50 states and Washington, DC) and US nativity. A dietary acculturation pattern was derived from 14 172 participants with two 24-hour dietary recalls at baseline (2008-2011) using least absolute shrinkage and selection operator regression, with food groups as predictors of US exposure. We evaluated associations of dietary acculturation with incident CVD across ≈7 years of follow-up (n=211/14 172 cases/total) and gut microbiota (n=2349; visit 2, 2014 to 2017). Serum metabolites associated with both dietary acculturation-related gut microbiota (n=694) and incident CVD (n=108/5256 cases/total) were used as proxy measures to assess the association of diet-related gut microbiome with incident CVD.

resultsWe identified an empirical US-oriented dietary acculturation score that increased with US exposure. Higher dietary acculturation score was associated with higher risk of incident CVD (hazard ratio per SD, 1.33 [95% CI, 1.13-1.57]), adjusted for sociodemographic, lifestyle, and clinical factors. Sixty-nine microbial species (17 enriched from diverse species, 52 depleted mainly from fiber-utilizing

conclusionsAmong US Hispanic and Latino adults, greater dietary acculturation was associated with elevated CVD risk, possibly through alterations in gut microbiota and related metabolites. Diet and microbiota-targeted interventions may offer opportunities to mitigate CVD burdens of dietary acculturation.

Indexed as

AcculturationCardiovascular DiseasesDietGastrointestinal MicrobiomeHispanic or LatinoAdultFemaleHumansIncidenceMaleMiddle AgedRisk FactorsUnited Statesacculturationcardiovascular diseasesgut microbiomeHispanic or Latinometabolome

Identifiers

PMID39008559
PMCPMC11460527

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