Evidence map›Paper›PMID 39008434›Full record

ArticleJournal of adolescent and young adult oncology2025

Harmonization of the Upfront Osteosarcoma Treatment Paradigm for Adolescents and Young Adults.

Nicole P Daukshus, Viswatej Avutu, Emily Long Sarro, Michael D Kinnaman, Emily K Slotkin, Katherine Thornton, Mark A Dickson, Nancy T Sklarin, William D Tap, Julia Glade Bender

Abstract read
In one paragraph

Article in Journal of adolescent and young adult oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicole P DaukshusDepartment of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0001-5975-1245
Viswatej AvutuDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0002-2591-7187
Emily Long SarroDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Michael D KinnamanDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Emily K SlotkinDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Katherine ThorntonDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Mark A DicksonDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Nancy T SklarinDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
William D TapDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Julia Glade BenderDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Limited guidance exists on streamlining cancer therapy for adolescent and young adult (AYA) patients 15-39 years of age, as much of the current data are extrapolated from pediatric or adult counterparts and can differ significantly between the two care models. Harmonization of standard treatment approaches has the potential to improve outcomes and establish a foundation for the development of future clinical trials. We present our experience harmonizing treatment and supportive care regimens for AYA patients with osteosarcoma receiving treatment with methotrexate, doxorubicin, and cisplatin (MAP) therapy on the pediatric and adult sarcoma services at the Memorial Sloan Kettering Cancer Center.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsBone NeoplasmsOsteosarcomaAdolescentAdultCisplatinDoxorubicinFemaleHumansMaleMethotrexateYoung AdultCisplatinDoxorubicinMethotrexateadolescent and young adultharmonizationosteosarcomatreatment

Identifiers

PMID39008434
PMCPMC12332384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.