Evidence map›Paper›PMID 39008130›Full record

ArticleLangenbeck's archives of surgery2024

Survival and prognostic factors of primary retroperitoneal sarcomas after surgery: a single-center experience.

Shuai Zhao, Jiajie Zhou, Ruiqi Li, Longhe Sun, Qiannan Sun, Wei Wang, Daorong Wang

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Article in Langenbeck's archives of surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Shuai Zhao *Clinical Teaching Hospital of Medical School, Northern Jiangsu People's Hospital, Nanjing University, Yangzhou, China.
Jiajie Zhou *Clinical Teaching Hospital of Medical School, Northern Jiangsu People's Hospital, Nanjing University, Yangzhou, China.
Ruiqi LiClinical Teaching Hospital of Medical School, Northern Jiangsu People's Hospital, Nanjing University, Yangzhou, China.
Longhe SunDepartment of General Surgery, Taizhou Fourth People's Hospital, Taizhou, China.
Qiannan SunDepartment of General Surgery, Northern Jiangsu People's Hospital, Yangzhou, China.
Wei WangDepartment of General Surgery, Northern Jiangsu People's Hospital, Yangzhou, China.
Daorong WangClinical Teaching Hospital of Medical School, Northern Jiangsu People's Hospital, Nanjing University, Yangzhou, China. wdaorong666@sina.com.

Funding

National Natural Science Foundation of China 82373014
6 · The paper itself

Abstract

purposeThe percentage of retroperitoneal sarcomas (RPS) among all soft tissue sarcomas ranges from 10 to 15%. Surgery remains the gold standard for RPS. In this study, we analyzed the impact of surgical treatment for primary RPS on recurrence and overall mortality at a Chinese institution and identified and evaluated prognostic variables.

methodsData from patients with RPS who underwent surgical treatment were retrospectively analyzed. The patients were treated at a single center from January 2000 to June 2018. Retrospectively collected demographic, clinicopathological, and surgical factors were examined. Overall survival (OS) and disease-free survival (DSF) were used as the primary endpoints. Predicted 5-year survival rates, encompassing both DFS and OS, were derived from the Sarculator prognostic nomogram.

resultsA total of 110 patients met the inclusion criteria. The median follow-up time after surgery for patients with primary RPS was 5.3 years. During this period, 59 patients died. The 5-year OS and DFS estimates were 63.5% and 35.3%, respectively. In a multivariate analysis, poor OS following surgical treatment of primary RPS was independently correlated with FNCLCC grade (p < 0.001) and surgical margin status (p = 0.016). FNCLCC grade (p = 0.001) and surgical margin status (p = 0.002) were also independently associated with poor DFS. The C-indices for 5-year OS and DFS survival utilizing the Sarculator prognostic nomogram were 0.71 and 0.73 respectively.

conclusionThe overall mortality rate of patients with RPS was considered acceptable. OS and DFS prognostic markers were established for primary RPS. Tumor grade and intraregional margins are other factors that affect survival and recurrence.

Indexed as

Retroperitoneal NeoplasmsSarcomaAdultAgedDisease-Free SurvivalFemaleHumansMaleMargins of ExcisionMiddle AgedNeoplasm Recurrence, LocalPrognosisRetrospective StudiesSurvival RateYoung AdultDisease-free survivalOverall survivalPrognostic factorsRetroperitoneal sarcomasSurgery

Identifiers

PMID39008130

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