Evidence map›Paper›PMID 39007997›Full record

Trial reportEuropean journal of nutrition2024

Influence of the CYP1A2 c.

David Varillas-Delgado, Juan Del Coso, Alejandro Muñoz, Millán Aguilar-Navarro, Jorge Gutierrez-Hellin

Erratum issued Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05975489 (Influence of the Genetic Polymorphisms in the Effect of Caffeine on Fat Oxidation During Exercise), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05975489 nacompletednot on this map

Influence of the Genetic Polymorphisms in the Effect of Caffeine on Fat Oxidation During Exercise

TypeinterventionalSponsorUniversidad Francisco de VitoriaRan2020 to 2022Enrolled32ConditionsGenetic Predisposition, Caffeine, Fat BurnArmsAcute caffeine supplementation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

David Varillas-DelgadoFaculty of Health Sciences, Universidad Francisco de Vitoria, Madrid, Spain.ORCID http://orcid.org/0000-0001-5026-2701
Juan Del CosoSport Sciences Research Centre, Rey Juan Carlos University, Madrid, Spain.ORCID http://orcid.org/0000-0002-5785-984X
Alejandro MuñozFaculty of Health Sciences, Universidad Francisco de Vitoria, Madrid, Spain. alejandro.munoz@ufv.es.ORCID http://orcid.org/0000-0001-7679-4116
Millán Aguilar-NavarroFaculty of Health Sciences, Universidad Francisco de Vitoria, Madrid, Spain.ORCID http://orcid.org/0000-0001-9130-9182
Jorge Gutierrez-HellinFaculty of Health Sciences, Universidad Francisco de Vitoria, Madrid, Spain.ORCID http://orcid.org/0000-0001-9721-2269

Funding

Universidad Francisco de Vitoria UFV-18/2020
6 · The paper itself

Abstract

purposeThe aim of this study was to determine the influence of the CYP1A2 c.-163 A > C (rs762551) polymorphism on the effect of oral caffeine intake on fat oxidation during exercise.

methodsUsing a pilot randomized, double-blind, crossover, placebo-controlled trial, 32 young and healthy individuals (women = 14, men = 18) performed an incremental test on a cycle ergometer with 3-min stages at workloads from 30 to 70% of maximal oxygen uptake (VO

resultsEight participants were genotyped as AA, 18 participants were CA heterozygotes, and 6 participants were CC. There was a main effect of substance (F = 3.348, p = 0.050) on fat oxidation rates during exercise with no genotype effect (F = 0.158, p = 0.959). The post hoc analysis revealed that, in comparison to the placebo, 3 and 6 mg/kg of caffeine increased fat oxidation at 40-50% VO

conclusionOral intake of 3 and 6 mg/kg of caffeine increased fat oxidation rate during aerobic exercise in individuals with AA, CA and CC genotypes. This suggests that the effect of caffeine to enhance fat oxidation during exercise is not influenced by the CYP1A2 c.-163 A > C polymorphism.

trial registrationThe study was registered on clinicaltrials.gov with ID: NCT05975489.

Indexed as

CaffeineCross-Over StudiesCytochrome P-450 CYP1A2ExerciseOxidation-ReductionAdultDouble-Blind MethodFemaleGenotypeHumansLipid MetabolismMaleOxygen ConsumptionPilot ProjectsPolymorphism, GeneticPolymorphism, Single NucleotideCaffeineCYP1A2 protein, humanCytochrome P-450 CYP1A2CYP1A2Endurance exerciseGeneticsLipidsSubstrate oxidation

Identifiers

PMID39007997

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.