Evidence map›Paper›PMID 39007822›Full record

ArticleJournal of synchrotron radiation2024

High-angular-sensitivity X-ray phase-contrast microtomography of soft tissue through a two-directional beam-tracking synchrotron set-up.

Carlos Navarrete-León, P Stephen Patrick, Adam Doherty, Harry Allan, Silvia Cipiccia, Shashidhara Marathe, Kaz Wanelik, Michela Esposito, Charlotte K Hagen, Alessandro Olivo and 1 more

Abstract read
In one paragraph

Article in Journal of synchrotron radiation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Carlos Navarrete-LeónDepartment of Medical Physics and Biomedical Engineering, University College London, Malet Place, Gower Street, London WC1E 6BT, United Kingdom.
P Stephen PatrickCentre for Advanced Biomedical Imaging, Division of Medicine, University College London, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, United Kingdom.ORCID 0000-0002-7155-1729
Adam DohertyDepartment of Medical Physics and Biomedical Engineering, University College London, Malet Place, Gower Street, London WC1E 6BT, United Kingdom.
Harry AllanDepartment of Medical Physics and Biomedical Engineering, University College London, Malet Place, Gower Street, London WC1E 6BT, United Kingdom.ORCID 0000-0002-7891-9346
Silvia CipicciaDepartment of Medical Physics and Biomedical Engineering, University College London, Malet Place, Gower Street, London WC1E 6BT, United Kingdom.
Shashidhara MaratheDiamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, United Kingdom.
Kaz WanelikDiamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot OX11 0DE, United Kingdom.
Michela EspositoDepartment of Medical Physics and Biomedical Engineering, University College London, Malet Place, Gower Street, London WC1E 6BT, United Kingdom.
Charlotte K HagenDepartment of Medical Physics and Biomedical Engineering, University College London, Malet Place, Gower Street, London WC1E 6BT, United Kingdom.
Alessandro OlivoDepartment of Medical Physics and Biomedical Engineering, University College London, Malet Place, Gower Street, London WC1E 6BT, United Kingdom.
Marco EndrizziDepartment of Medical Physics and Biomedical Engineering, University College London, Malet Place, Gower Street, London WC1E 6BT, United Kingdom.

Funding

Engineering and Physical Sciences Research Council EP/R511638/1Engineering and Physical Sciences Research Council EP/T005408/1Engineering and Physical Sciences Research Council EP/T02593X/1Engineering and Physical Sciences Research Council EP/V035932/1Medical Research Council MR/R026416/1Wellcome TrustWellcome Trust 221367/Z/20/ZWellcome Trust 562448
6 · The paper itself

Abstract

Two-directional beam-tracking (2DBT) is a method for phase-contrast imaging and tomography that uses an intensity modulator to structure the X-ray beam into an array of independent circular beamlets that are resolved by a high-resolution detector. It features isotropic spatial resolution, provides two-dimensional phase sensitivity, and enables the three-dimensional reconstructions of the refractive index decrement, δ, and the attenuation coefficient, μ. In this work, the angular sensitivity and the spatial resolution of 2DBT images in a synchrotron-based implementation is reported. In its best configuration, angular sensitivities of ∼20 nrad and spatial resolution of at least 6.25 µm in phase-contrast images were obtained. Exemplar application to the three-dimensional imaging of soft tissue samples, including a mouse liver and a decellularized porcine dermis, is also demonstrated.

Indexed as

Imaging, Three-DimensionalSynchrotronsX-Ray MicrotomographyAnimalsLiverMiceSwinebioimagingphase-contrast imagingtomography

Identifiers

PMID39007822
PMCPMC11371031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.