Evidence map›Paper›PMID 39007759›Full record

ArticleJournal of medicinal chemistry2024

Identification of 6-Anilino Imidazo[4,5-

Cho R Hong, Lydia P Liew, Way W Wong, Benjamin D Dickson, Gary Cheng, Avik Shome, Rebecca Airey, Jagdish Jaiswal, Barbara Lipert, Stephen M F Jamieson and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cho R HongAuckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Lydia P LiewAuckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Way W WongAuckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Benjamin D DicksonChemistry and Applied Physics, School of Science, University of Waikato, Private Bag 3105, Hamilton 3240, New Zealand.ORCID 0000-0001-6860-903X
Gary ChengAuckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Avik ShomeAuckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Rebecca AireyAuckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Jagdish JaiswalAuckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Barbara LipertAuckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Stephen M F JamiesonAuckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.ORCID 0000-0002-5485-9211
William R WilsonAuckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Michael P HayAuckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.ORCID 0000-0002-7087-9087

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dominant role of non-homologous end-joining in the repair of radiation-induced double-strand breaks identifies DNA-dependent protein kinase (DNA-PK) as an excellent target for the development of radiosensitizers. We report the discovery of a new class of imidazo[4,5-

Indexed as

DNA-Activated Protein KinaseProtein Kinase InhibitorsRadiation-Sensitizing AgentsAnimalsCell Line, TumorHumansImidazolesMiceMice, NudePyridonesRatsStructure-Activity RelationshipXenograft Model Antitumor AssaysDNA-Activated Protein KinaseImidazolesProtein Kinase InhibitorsPyridonesRadiation-Sensitizing Agents

Identifiers

PMID39007759
PMCPMC11284801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.