ArticleMovement disorders : official journal of the Movement Disorder Society2024
Pilot Study of Acute Behavioral Effects of Pallidal Burst Stimulation in Parkinson's Disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Burst deep brain stimulation for Parkinson's disease: A systematic review of efficacy and safety.Journal of Parkinson's disease · 2026Review
- Harnessing synaptic plasticity for sustained motor improvement in Parkinson's disease.Neural regeneration research · 2026Article
- Proceedings of the 13th annual deep brain stimulation think tank: the evolving landscape.Frontiers in human neuroscience · 2026Review
- Adaptive neuromodulation dialogues: navigating current challenges and emerging innovations in neuromodulation system development.Journal of neural engineering · 2025Review
- Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans.Nature neuroscience · 2025Review
- Calcium-based synaptic and structural plasticity link pathological activity to synaptic reorganization in Parkinson's disease.Science advances · 2025Article
- Modulating inhibitory synaptic plasticity to restore basal ganglia dynamics in Parkinson's disease.Brain : a journal of neurology · 2025Article
- Site-specific neuronal and motor effects of short-term intermittent burst deep brain stimulation in non-human primates.Brain stimulationArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundBurst-patterned pallidal deep brain stimulation (DBS) in an animal model of Parkinson's disease (PD) yields significantly prolonged therapeutic benefit compared to conventional continuous DBS, but its value in patients remains unclear.
objectivesThe aims were to evaluate the safety and tolerability of acute (<2 hours) burst DBS in PD patients and to evaluate preliminary clinical effectiveness relative to conventional DBS.
methodsSix PD patients were studied with DBS OFF, conventional DBS, and burst DBS. Unified Parkinson's Disease Rating Scale III (UPDRS-III) and proactive inhibition (using stop-signal task) were evaluated for each condition.
resultsBurst and conventional DBS were equally tolerated without significant adverse events. Both stimulation patterns provided equivalent significant UPDRS-III reduction and increased proactive inhibition relative to DBS OFF.
conclusionsThis pilot study supports the safety and tolerability of burst DBS, with acute effects similar to conventional DBS. Further larger-scale studies are warranted given the potential benefits of burst DBS due to decreased total energy delivery. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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Registered trials
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