Evidence map›Paper›PMID 39007444›Full record

ArticleAnnals of neurology2024

Cancer Frequency in MuSK Myasthenia Gravis and Histological Evidence of Paraneoplastic Etiology.

Silvia Falso, Marco Gessi, Sofia Marini, Roberta Benvenuto, Eleonora Sabatelli, Antonio D'Amati, Martina Marini, Amelia Evoli, Raffaele Iorio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Silvia FalsoDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.
Marco GessiNeuropathology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Sofia MariniDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.
Roberta BenvenutoNeuropathology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Eleonora SabatelliNeurology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Antonio D'AmatiGynecopathology and Breast Pathology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.ORCID 0000-0002-4810-1201
Martina MariniDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.
Amelia EvoliDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID 0000-0002-4644-2299
Raffaele IorioDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID 0000-0002-6270-0956

Funding

Rare Disease Network for Myasthenia GravisU54NS115054 · NINDS · GEORGE WASHINGTON UNIVERSITY · PI HENRY J KAMINSKI · 2019 to 2026
$11.9M
NINDS NIH HHS U54 NS115054
6 · The paper itself

Abstract

Cancer frequency in muscle-specific kinase myasthenia gravis (MuSK-MG) has not yet been explored and the mechanisms leading to the formation of MuSK IgG remain elusive. We aimed to explore cancer frequency in MuSK-MG patients and to assess MuSK expression in cancer cells from 2 tumors occurred in this cohort. Immunohistochemistry on tumor specimens revealed the expression of MuSK in the cancer cells from primary mediastinal B cell lymphoma and endometrial carcinoma. Twenty-one males and 73 females were enrolled. Fifteen cancers occurred in 13 of 94 patients (13.8%). Patients with cancer were significantly older at time of MuSK-MG onset. ANN NEUROL 2024;96:1020-1025.

Indexed as

Myasthenia GravisReceptor Protein-Tyrosine KinasesReceptors, CholinergicAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeoplasmsYoung AdultMUSK protein, humanReceptor Protein-Tyrosine KinasesReceptors, Cholinergic

Identifiers

PMID39007444
PMCPMC11496004

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.