Evidence map›Paper›PMID 39007437›Full record

ArticleJournal of extracellular vesicles2024

CD66b

Rosa Suades, Maria Francesca Greco, Paula Prieto, Teresa Padró, Yvan Devaux, Pere Domingo, Lina Badimon

Abstract read
In one paragraph

Article in Journal of extracellular vesicles, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. CD66bJournal of extracellular vesicles · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rosa SuadesCardiovascular Program ICCC, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain.ORCID https://orcid.org/0000-0002-0193-3115
Maria Francesca GrecoCardiovascular Program ICCC, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain.ORCID https://orcid.org/0000-0003-3613-5516
Paula PrietoInfectious Diseases Unit, Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau - IR SANT PAU, Barcelona, Spain.
Teresa PadróCardiovascular Program ICCC, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain.ORCID https://orcid.org/0000-0003-1921-954X
Yvan DevauxCardiovascular Research Unit, Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg.ORCID https://orcid.org/0000-0002-5321-8543
Pere DomingoInfectious Diseases Unit, Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau - IR SANT PAU, Barcelona, Spain.ORCID https://orcid.org/0000-0003-1138-5770
Lina BadimonCardiovascular Program ICCC, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain.ORCID https://orcid.org/0000-0002-9162-2459

Funding

Agéncia de Gestió d'Ajuts Universitaris i de Recerca 2019BP00211Agencia Estatal de Investigación PID2019-107160RB-I00Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares CB16/11/00411H2020 Societal Challenges 101016072Instituto de Salud Carlos III CoV20/00070Instituto de Salud Carlos III PI19/01687
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) has been a major public health burden. We hypothesised that circulating extracellular vesicles (cEVs), key players in health and disease, could trace the cell changes during COVID-19 infection and recovery. Therefore, we studied the temporal trend of cEV and inflammatory marker levels in plasma samples of COVID-19 patients that were collected within 24 h of patient admission (baseline, n = 80) and after hospital discharge at day-90 post-admission (n = 59). Inflammatory markers were measured by standard biochemical methods. cEVs were quantitatively and phenotypically characterized by high-sensitivity nano flow cytometry. In patients recovered from COVID-19 lower levels of inflammatory markers were detected. cEVs from vascular (endothelial cells) and blood (platelets, distinct immune subsets) cells were significantly reduced at day-90 compared to admission levels, a pattern also observed for cEVs from progenitor, perivascular and epithelial cells. The best discriminatory power for COVID-19 severity was found for inflammatory markers lactate dehydrogenase and neutrophil-to-lymphocyte ratio and for granulocyte/macrophage-released CD66b

Indexed as

COVID-19Extracellular VesiclesL-Lactate DehydrogenaseLymphocytesNeutrophilsSARS-CoV-2AdultAgedAntigens, CDBiomarkersCell Adhesion MoleculesFemaleGPI-Linked ProteinsHumansMaleMiddle AgedAntigens, CDBiomarkersCEACAM8 protein, humanCell Adhesion MoleculesGPI-Linked ProteinsL-Lactate Dehydrogenasecoronavirus disease 2019extracellular vesiclesinflammatory markersmicrovesiclessevere acute respiratory syndrome coronavirus‐2

Identifiers

PMID39007437
PMCPMC11247396

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.