Evidence map›Paper›PMID 39007407›Full record

ArticleJournal of cachexia, sarcopenia and muscle2024

Mitochondrial bioenergetics are not associated with myofibrillar protein synthesis rates.

Andrew M Holwerda, Marlou L Dirks, Pierre-Andre Barbeau, Joy Goessens, Annemie Gijsen, Luc J C van Loon, Graham P Holloway

Abstract read
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrew M HolwerdaNUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.ORCID 0000-0002-7926-4863
Marlou L DirksNUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Pierre-Andre BarbeauDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada.
Joy GoessensNUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Annemie GijsenNUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Luc J C van LoonNUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Graham P HollowayDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada.

Funding

Natural Sciences and Engineering Research Council of Canada (NSERC) 400362
6 · The paper itself

Abstract

backgroundMitochondria represent key organelles influencing cellular homeostasis and have been implicated in the signalling events regulating protein synthesis.

methodsWe examined whether mitochondrial bioenergetics (oxidative phosphorylation and reactive oxygen species (H

resultsNeither oxidative phosphorylation nor H

conclusionsMitochondrial oxidative phosphorylation and reactive oxygen emission do not seem to represent key factors regulating muscle protein synthesis or muscle mass regulation across the spectrum of physical activity.

Indexed as

Energy MetabolismMuscle ProteinsMyofibrilsProtein BiosynthesisAdultAgedAnimalsHumansMaleMiceMitochondriaMuscle, SkeletalOxidative PhosphorylationReactive Oxygen SpeciesYoung AdultMuscle ProteinsReactive Oxygen SpeciesAgingMuscle protein synthesisPhysical inactivityReactive oxygen speciesSkeletal muscle

Identifiers

PMID39007407
PMCPMC11446679

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.