Evidence map›Paper›PMID 39007209›Full record

ArticleChemical communications (Cambridge, England)2024

Light-activated azobenzene peptide inhibitor of the PD-1/PD-L1 interaction.

Deanne Hayward, Zoë R Goddard, Marco M D Cominetti, Mark Searcey, Andrew M Beekman

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Deanne HaywardSchool of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, Norfolk, NR47TJ, UK. A.Beekman@uea.ac.uk.
Zoë R GoddardSchool of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, Norfolk, NR47TJ, UK. A.Beekman@uea.ac.uk.ORCID 0000-0002-7900-1553
Marco M D CominettiSchool of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, Norfolk, NR47TJ, UK. A.Beekman@uea.ac.uk.
Mark SearceySchool of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, Norfolk, NR47TJ, UK. A.Beekman@uea.ac.uk.ORCID 0000-0003-2273-8949
Andrew M BeekmanSchool of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, Norfolk, NR47TJ, UK. A.Beekman@uea.ac.uk.ORCID 0000-0002-3056-6406

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhibiting the PD-1/PD-L1 protein-protein interaction is a key immunotherapy for cancer. Antibodies dominate the clinical space but are costly, with limited applicability and immune side effects. We developed a photo-controlled azobenzene peptide that selectively inhibits the PD-1/PD-L1 interaction when in the

Indexed as

Azo CompoundsB7-H1 AntigenLightPeptidesProgrammed Cell Death 1 ReceptorHumansProtein BindingazobenzeneAzo CompoundsB7-H1 AntigenCD274 protein, humanPDCD1 protein, humanPeptidesProgrammed Cell Death 1 Receptor

Identifiers

PMID39007209
PMCPMC11293026

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.